BACKGROUND Hypertrophic cardiomyopathy (HCM) is associated with heart failure, atrial fibrillation and sudden death. Reduced myocardial function has been reported in HCM despite normal left ventricular (LV) ejection fraction. Additionally, LV fibrosis is associated with elevated T1 and might be an outcome predictor. OBJECTIVE To systematically compare tissue phase mapping and feature tracking for assessing regional LV function in children and young adults with HCM and pediatric controls, and to evaluate structure-function relationships among myocardial velocities, LV wall thickness and myocardial T1. MATERIALS AND METHODS Seventeen pediatric patients with HCM and 21 age-matched controls underwent cardiac MRI including standard cine imaging, tissue phase mapping (two-dimensional cine phase contrast with three-directional velocity encoding), and modified Look-Locker inversion recovery to calculate native global LV T1. Maximum LV wall thickness was measured on cine images. LV radial, circumferential and long-axis myocardial velocity time courses, as well as global and segmental systolic and diastolic peak velocities, were quantified from tissue phase mapping and feature tracking. RESULTS Both tissue phase mapping and feature tracking detected significantly decreased global and segmental diastolic radial and long-axis peak velocities (by 12-51%, P<0.001-0.05) in pediatric patients with HCM vs. controls. Feature tracking peak velocities were lower than directly measured tissue phase mapping velocities (mean bias = 0.3-2.9 cm/s). Diastolic global peak velocities correlated moderately with global T1 (r = -0.57 to -0.72, P<0.01) and maximum wall thickness (r = -0.37 to -0.61, P<0.05). CONCLUSION Both tissue phase mapping and feature tracking detected myocardial velocity changes in children and young adults with HCM vs. controls. Associations between impaired diastolic LV velocities and elevated T1 indicate structure-function relationships in HCM.

中文翻译：

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在肥厚型心肌病的小儿患者中，通过组织相图和特征跟踪改变了局部心肌的速度。

背景技术肥厚型心肌病（HCM）与心力衰竭，心房颤动和猝死有关。尽管左心室（LV）射血分数正常，但仍有报道HCM的心肌功能降低。此外，LV纤维化与T1升高有关，可能是预后指标。目的系统地比较组织相图和特征追踪，以评估患有HCM和儿科控制的儿童和年轻人的局部左室功能，并评估心肌速度，左室壁厚度和心肌T1之间的结构-功能关系。材料与方法17例HCM小儿患者和21名年龄匹配的对照者接受了心脏MRI检查，包括标准的电影成像，组织相位图（二维电影相位对比和三向速度编码），并修改了Look-Locker反演恢复以计算本机全局LV T1。在电影图像上测量最大LV壁厚。LV径向，圆周和长轴心肌速度的时间进程，以及整体和分段收缩和舒张峰值速度，从组织相图和特征跟踪进行量化。结果与对照组相比，小儿HCM患者的组织相图和特征追踪均检测到显着降低了整体和节段舒张期radial骨和长轴峰值速度（降低了12-51％，P <0.001-0.05）。特征跟踪峰值速度低于直接测量的组织相图速度（平均偏差= 0.3-2.9 cm / s）。舒张压总峰值速度与总T1（r = -0.57至-0.72，P <0.01）和最大壁厚（r = -0.37至-0.61，P <0）适度相关。05）。结论组织相图和特征跟踪都检测到了HCM与对照组的儿童和年轻人的心肌速度变化。舒张压左室速度减慢和T1升高之间的关联表明HCM中的结构功能关系。