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The role of bone cells in immune regulation during the course of infection.
Seminars in Immunopathology ( IF 9 ) Pub Date : 2019-09-24 , DOI: 10.1007/s00281-019-00755-2
Asuka Terashima 1 , Hiroshi Takayanagi 2
Affiliation  

Bone homeostasis depends on a balance between osteoclastic bone resorption and osteoblastic bone formation. Bone cells are regulated by a variety of biochemical factors, such as hormones and cytokines, as well as various types of physical stress. The immune system affects bone, since such factors are dysregulated under pathologic conditions, including infection. The bone marrow, one of the primary lymphoid organs, provides a special microenvironment that supports the function and differentiation of immune cells and hematopoietic stem cells (HSCs). Thus, bone cells contribute to immune regulation by modulating immune cell differentiation and/or function through the maintenance of the bone marrow microenvironment. Although osteoblasts were first reported as the population that supports HSCs, the role of osteoblast-lineage cells in hematopoiesis has been shown to be more limited than previously expected. Osteoblasts are specifically involved in the differentiation of lymphoid cells under physiological and pathological conditions. It is of critical importance how bone cells are modified during inflammation and/or infection and how such modification affects the immune system.

中文翻译:

骨细胞在感染过程中在免疫调节中的作用。

骨稳态取决于破骨细胞吸收与成骨细胞形成之间的平衡。骨细胞受多种生化因素(例如激素和细胞因子)以及各种类型的身体压力的调节。免疫系统会影响骨骼,因为这些因素在包括感染在内的病理状况下均失调。骨髓是主要的淋巴器官之一,提供了特殊的微环境,可支持免疫细胞和造血干细胞(HSC)的功能和分化。因此,骨细胞通过维持骨髓微环境来调节免疫细胞的分化和/或功能,从而有助于免疫调节。尽管成骨细胞是最早报道支持HSC的人群,已经表明,成骨细胞系细胞在造血中的作用比以前预期的更为有限。成骨细胞在生理和病理条件下特别参与淋巴样细胞的分化。至关重要的是在炎症和/或感染期间如何修饰骨细胞,以及这种修饰如何影响免疫系统。
更新日期:2019-09-24
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