This population-based ecological study analyzes the prevalence of childhood leukemia in Ukraine before and after the Chornobyl nuclear power plant accident, based on the contamination status of the territory, time period, gender, and age. Three regions-Zhytomyr, Kyiv (except Kyiv city), and Chernihiv were included as areas contaminated by radioactive 137Cs from 1 to 15 Ci/km2 with annual effective doses exceeding 1.0 mSv, and Sumy region as the control (non-contaminated) area with 137Cs contamination less than 1 Ci/km2 and effective doses less than 0.5 mSv per year. The integrated database of the National Research Centre for Radiation Medicine used in the present study included 1085 childhood leukemia cases. Two aggregated periods were used for analysis: 1980-1986 (pre-accident) and 1987-2000 (post-accident). ICD-9 codes for leukemia (204-208.9) were used to perform analyses according to the extent of leukemic cells maturity (acute, chronic, and maturity unspecified leukemia), leukemic cell lineage (lymphoid, myeloid and lineage unspecified leukemia) and all leukemia cases in different age subgroups (1-4, 5-9, 10-14, and 15-19 years). Standard methods of descriptive epidemiology were used to calculate the prevalence of disease and frequency ratio in regression models. A statistically significant increase in frequency ratio for acute leukemia (1.44; 95% confidence interval (CI), 1.22-1.71), myeloid leukemia (2.93; 95% CI, 1.71-5.40), cell lineage unspecified leukemia (II) (1.48; 95% CI, 1.18-1.87) and all forms of leukemia (1.59; 95% CI, 1.36-1.86) was found for the post-accident period in highly contaminated areas. The results indicate that the frequency of childhood leukemia (and of some of its types) increased in contaminated areas during the post-accident period, suggesting that radiation exposure after the Chornobyl accident might be the cause of the increase. However, further analytical studies, with individual or at least group dose estimates, are needed to confirm a link between childhood leukemia and the Chornobyl accident.

中文翻译：

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霍诺贝利事故后的乌克兰儿童白血病。

这项基于人群的生态研究根据领土，时间段，性别和年龄的污染状况，分析了在霍诺贝利核电站事故发生前后乌克兰儿童白血病的患病率。Zhytomyr，Kyiv（除Kyiv市以外）和Chernihiv这三个地区被包括为放射性137Cs污染范围为1至15 Ci / km2，年有效剂量超过1.0 mSv的地区，Sumy地区为对照（非污染）地区，每年137 Cs污染小于1 Ci / km2，有效剂量小于0.5 mSv。本研究中使用的国家放射医学研究中心的综合数据库包括1085例儿童白血病病例。分析使用了两个汇总时段：1980-1986年（事故前）和1987-2000年（事故后）。ICD-9编码为白血病（204-208。9）根据白血病细胞的成熟度（急性，慢性和成熟度未指明的白血病），白血病细胞谱系（淋巴，髓样和谱系未指明的白血病）以及所有不同年龄组的白血病病例（1-4）进行分析，5-9、10-14和15-19岁）。描述性流行病学的标准方法用于计算回归模型中的疾病患病率和频率比率。急性白血病（1.44; 95％置信区间（CI），1.22-1.71），髓样白血病（2.93; 95％CI，1.71-5.40），细胞谱系未明白血病（II）（1.48;在高污染地区的事故后期间发现了95％CI（1.18-1.87）和所有形式的白血病（1.59； 95％CI，1.36-1.86）。结果表明，在事故后期间，受污染地区的儿童白血病（及其某些类型）的发生率增加，这表明霍诺贝利事故发生后的辐射暴露可能是造成这种情况的原因。然而，需要进一步的分析研究，以个人或至少团体剂量估计，以确认儿童白血病与霍诺贝利事故之间的联系。