当前位置:
X-MOL 学术
›
Biol. Sex Differ.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Sex hormones, aging and cardiometabolic syndrome.
Biology of Sex Differences ( IF 7.9 ) Pub Date : 2019-07-01 , DOI: 10.1186/s13293-019-0246-6 Jessica L Faulkner 1 , Eric J Belin de Chantemèle 1
Biology of Sex Differences ( IF 7.9 ) Pub Date : 2019-07-01 , DOI: 10.1186/s13293-019-0246-6 Jessica L Faulkner 1 , Eric J Belin de Chantemèle 1
Affiliation
It is well documented that the metabolic syndrome predisposes patients to increased cardiovascular risk. Emerging data indicates that cardiovascular risk conferred by metabolic syndrome is highly dependent on sex and sex hormone status throughout the lifetime. Both male and female sex hormones, as well as sex chromosomes themselves, contribute to the development of obesity and intervene in the control of insulin homeostasis and blood pressure. Furthermore, men and women develop age-associated cardiometabolic risk in a sex-specific fashion in association with changes in these sex hormonal levels. Therefore, the current notion of the metabolic syndrome as a sex-independent diagnosis is antiquated, and novel studies and clinical trials utilizing these known sex differences in the development of metabolic dysregulation and cardiometabolic risk are warranted.
中文翻译:
性激素,衰老和心脏代谢综合征。
有充分的文献证明,代谢综合征使患者更易患心血管疾病。新兴数据表明,代谢综合征所致的心血管风险在整个生命过程中高度依赖于性别和性激素状态。男性和女性性激素以及自身的性染色体均有助于肥胖症的发展,并干预胰岛素稳态和血压的控制。此外,随着这些性激素水平的变化,男人和女人以与性别相关的方式发展与年龄相关的心脏代谢风险。因此,目前将代谢综合症作为一种与性别无关的诊断的概念是过时的,
更新日期:2020-04-22
中文翻译:
性激素,衰老和心脏代谢综合征。
有充分的文献证明,代谢综合征使患者更易患心血管疾病。新兴数据表明,代谢综合征所致的心血管风险在整个生命过程中高度依赖于性别和性激素状态。男性和女性性激素以及自身的性染色体均有助于肥胖症的发展,并干预胰岛素稳态和血压的控制。此外,随着这些性激素水平的变化,男人和女人以与性别相关的方式发展与年龄相关的心脏代谢风险。因此,目前将代谢综合症作为一种与性别无关的诊断的概念是过时的,