当前位置:
X-MOL 学术
›
Emerg. Microbes Infect.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Simultaneous outbreaks of respiratory disease in wild chimpanzees caused by distinct viruses of human origin.
Emerging Microbes & Infections ( IF 13.2 ) Pub Date : 2019-01-01 , DOI: 10.1080/22221751.2018.1563456 Jacob D Negrey 1 , Rachna B Reddy 2 , Erik J Scully 3 , Sarah Phillips-Garcia 4 , Leah A Owens 5 , Kevin E Langergraber 6 , John C Mitani 2 , Melissa Emery Thompson 4 , Richard W Wrangham 3 , Martin N Muller 4 , Emily Otali 7 , Zarin Machanda 8 , David Hyeroba 7 , Kristine A Grindle 5 , Tressa E Pappas 5 , Ann C Palmenberg 5 , James E Gern 5 , Tony L Goldberg 5
Emerging Microbes & Infections ( IF 13.2 ) Pub Date : 2019-01-01 , DOI: 10.1080/22221751.2018.1563456 Jacob D Negrey 1 , Rachna B Reddy 2 , Erik J Scully 3 , Sarah Phillips-Garcia 4 , Leah A Owens 5 , Kevin E Langergraber 6 , John C Mitani 2 , Melissa Emery Thompson 4 , Richard W Wrangham 3 , Martin N Muller 4 , Emily Otali 7 , Zarin Machanda 8 , David Hyeroba 7 , Kristine A Grindle 5 , Tressa E Pappas 5 , Ann C Palmenberg 5 , James E Gern 5 , Tony L Goldberg 5
Affiliation
Respiratory viruses of human origin infect wild apes across Africa, sometimes lethally. Here we report simultaneous outbreaks of two distinct human respiratory viruses, human metapneumovirus (MPV; Pneumoviridae: Metapneumovirus) and human respirovirus 3 (HRV3; Paramyxoviridae; Respirovirus, formerly known as parainfluenza virus 3), in two chimpanzee (Pan troglodytes schweinfurthii) communities in the same forest in Uganda in December 2016 and January 2017. The viruses were absent before the outbreaks, but each was present in ill chimpanzees from one community during the outbreak period. Clinical signs and gross pathologic changes in affected chimpanzees closely mirrored symptoms and pathology commonly observed in humans for each virus. Epidemiologic modelling showed that MPV and HRV3 were similarly transmissible (R0 of 1.27 and 1.48, respectively), but MPV caused 12.2% mortality mainly in infants and older chimpanzees, whereas HRV3 caused no direct mortality. These results are consistent with the higher virulence of MPV than HRV3 in humans, although both MPV and HRV3 cause a significant global disease burden. Both viruses clustered phylogenetically within groups of known human variants, with MPV closely related to a lethal 2009 variant from mountain gorillas (Gorilla beringei beringei), suggesting two independent and simultaneous reverse zoonotic origins, either directly from humans or via intermediary hosts. These findings expand our knowledge of human origin viruses threatening wild chimpanzees and suggest that such viruses might be differentiated by their comparative epidemiological dynamics and pathogenicity in wild apes. Our results also caution against assuming common causation in coincident outbreaks.
中文翻译:
野生黑猩猩同时爆发由不同的人类病毒引起的呼吸道疾病。
源自人类的呼吸道病毒会感染整个非洲的野生猿类,有时甚至是致命的。在这里,我们报告在两个黑猩猩 (Pan troglodytes schweinfurthii) 群落中同时爆发了两种不同的人类呼吸道病毒,即人类偏肺病毒 (MPV; Pneumoviridae: Metapneumovirus) 和人类呼吸道病毒 3 (HRV3; 副粘病毒科; 呼吸道病毒,以前称为副流感病毒 3)。 2016 年 12 月和 2017 年 1 月在乌干达的同一片森林。病毒在暴发前不存在,但在暴发期间,每种病毒都存在于一个社区的患病黑猩猩身上。受影响黑猩猩的临床症状和总体病理变化与人类常见的每种病毒的症状和病理变化密切相关。流行病学模型显示 MPV 和 HRV3 具有相似的传染性(R0 分别为 1.27 和 1.48),但 MPV 主要在婴儿和老年黑猩猩中造成 12.2% 的死亡率,而 HRV3 没有直接导致死亡率。这些结果与 MPV 在人类中的毒力高于 HRV3 一致,尽管 MPV 和 HRV3 都会导致严重的全球疾病负担。这两种病毒在系统发育上都聚集在已知的人类变体组中,MPV 与 2009 年来自山地大猩猩(Gorilla beringei beringei)的致命变体密切相关,这表明两个独立且同时的反向人畜共患病起源,直接来自人类或通过中间宿主。这些发现扩展了我们对威胁野生黑猩猩的人源病毒的认识,并表明这些病毒可能通过它们在野生猿类中的比较流行病学动态和致病性来区分。
更新日期:2019-11-01
中文翻译:
野生黑猩猩同时爆发由不同的人类病毒引起的呼吸道疾病。
源自人类的呼吸道病毒会感染整个非洲的野生猿类,有时甚至是致命的。在这里,我们报告在两个黑猩猩 (Pan troglodytes schweinfurthii) 群落中同时爆发了两种不同的人类呼吸道病毒,即人类偏肺病毒 (MPV; Pneumoviridae: Metapneumovirus) 和人类呼吸道病毒 3 (HRV3; 副粘病毒科; 呼吸道病毒,以前称为副流感病毒 3)。 2016 年 12 月和 2017 年 1 月在乌干达的同一片森林。病毒在暴发前不存在,但在暴发期间,每种病毒都存在于一个社区的患病黑猩猩身上。受影响黑猩猩的临床症状和总体病理变化与人类常见的每种病毒的症状和病理变化密切相关。流行病学模型显示 MPV 和 HRV3 具有相似的传染性(R0 分别为 1.27 和 1.48),但 MPV 主要在婴儿和老年黑猩猩中造成 12.2% 的死亡率,而 HRV3 没有直接导致死亡率。这些结果与 MPV 在人类中的毒力高于 HRV3 一致,尽管 MPV 和 HRV3 都会导致严重的全球疾病负担。这两种病毒在系统发育上都聚集在已知的人类变体组中,MPV 与 2009 年来自山地大猩猩(Gorilla beringei beringei)的致命变体密切相关,这表明两个独立且同时的反向人畜共患病起源,直接来自人类或通过中间宿主。这些发现扩展了我们对威胁野生黑猩猩的人源病毒的认识,并表明这些病毒可能通过它们在野生猿类中的比较流行病学动态和致病性来区分。