Follicular lymphoma (FL) is an indolent lymphoma that often transforms into a high-grade lymphoma, mostly diffuse large B-cell lymphoma. A case of FL suggested to transform into plasmablastic lymphoma is presented. A 59-year-old man was admitted to our hospital because of right lower abdominal pain and vomiting. Computed tomography showed a mass in the ileocecum. Colonoscopy showed a mass with an ulcer in the ascending colon, and surgery was performed. Immunohistochemical staining of the biopsied mass showed infiltrated lymphocytes that were positive for CD38, CD45, CD138, and λ chain, and negative for CD4, CD5, CD8, CD10, CD20, CD56, and κ chain. Flow cytometric analysis of the ascites showed similar results. FISH analyses performed using lymph node biopsy specimens, ascite fluid and pleural effusion fluid identified the presence of an IGH/BCL2 translocation. FL was suggested to transform into PBL. Although the patient received three courses of R-CHOP chemotherapy and salvage chemotherapy, the patient died because of lymphoma progression less than 6 months after the diagnosis of PBL. Transformation of FL to PBL is highly unusual. The lack of a standard treatment for PBL results in the poor outcome of this entity. Novel therapeutic approaches are needed.

中文翻译：

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滤泡性淋巴瘤建议转变为EBV阴性的浆母细胞淋巴瘤。

滤泡性淋巴瘤（FL）是一种惰性的淋巴瘤，通常会转变成高级淋巴瘤，主要是弥漫性大B细胞淋巴瘤。提出了一例建议转化为浆母细胞淋巴瘤的FL病例。一名59岁的男子因右下腹疼痛和呕吐入院。计算机体层摄影术显示回肠盲肠肿块。结肠镜检查显示升结肠中有溃疡的肿块，并进行了手术。活检组织的免疫组织化学染色显示，浸润的淋巴细胞对CD38，CD45，CD138和λ链呈阳性，而对CD4，CD5，CD8，CD10，CD20，CD56和κ链呈阴性。腹水的流式细胞仪分析显示了相似的结果。使用淋巴结活检标本进行FISH分析，腹水和胸腔积液确定了IGH / BCL2易位。建议将FL转化为PBL。尽管患者接受了三个疗程的R-CHOP化疗和挽救性化疗，但由于诊断为PBL后不到6个月，患者因淋巴瘤进展而死亡。FL向PBL的转换非常不寻常。缺乏针对PBL的标准治疗方法会导致该个体的预后不良。需要新颖的治疗方法。缺乏针对PBL的标准治疗方法会导致该个体的预后不良。需要新颖的治疗方法。缺乏针对PBL的标准治疗方法会导致该个体的预后不良。需要新颖的治疗方法。