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The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein.
Genes & Development ( IF 10.5 ) Pub Date : 1996-08-01 , DOI: 10.1101/gad.10.15.1953
M Basson 1 , H R Horvitz
Affiliation  

Neuronal and mesodermal cell types are generated in separate cell lineages during the larval development of Caenorhabditis elegans. Here we demonstrate that the gene sem-4 is required in both types of lineages for the normal development of neuronal and mesodermal cell types. The sem-4 gene encodes a protein containing seven zinc finger motifs of the C2H2 class, four of which are arranged in two pairs widely separated in the primary sequence of the protein. These pairs of zinc fingers are similar to pairs of zinc fingers in the protein encoded by the Drosophila homeotic gene spalt and in the human transcription factor PRDII-BF1. Analysis of sem-4 alleles suggests that different zinc fingers in the SEM-4 protein may function differentially in neuronal and mesodermal cell types. We propose that sem-4 interacts with different transcription factors in different cell types to control the transcription of genes that function in the processes of neuronal and mesodermal cell development.

中文翻译:

秀丽隐杆线虫基因sem-4控制神经元和中胚层细胞发育,并编码锌指蛋白。

在秀丽隐杆线虫幼虫发育期间,神经元和中胚层细胞类型在单独的细胞谱系中产生。在这里,我们证明了在两种谱系中,神经元和中胚层细胞类型的正常发育都需要基因sem-4。sem-4基因编码一种蛋白质,该蛋白质包含七个C2H2类锌指基序,其中四个锌基序成两对,在蛋白质的一级序列中广泛隔开。这对锌指在果蝇同源基因spalt编码的蛋白质和人类转录因子PRDII-BF1中类似于锌指。对sem-4等位基因的分析表明,SEM-4蛋白中不同的锌指在神经元和中胚层细胞类型中的功能可能不同。
更新日期:2019-11-01
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