The pharmacological therapy for gastrointestinal (GI) diseases, such as inflammatory bowel diseases, continues to present challenges in targeting efficacy. The need for maximal local drug exposure at the inflamed regions of the GI tract has led research to focus on a disease‐targeted drug delivery approach. Smart nanomaterials responsive to the reactive oxygen species (ROS) concentrated in the inflamed areas, can be formulated into nanoplatforms to selectively release the active compounds, avoiding unspecific drug delivery to healthy tissues and limiting systemic absorption. Recent developments of ROS‐responsive nanoplatforms include combination with other materials to obtain multi‐responsive systems and modifications/derivatization to increase the interactions with biological tissues, cell uptake and targeting. This review describes the applications of ROS‐responsive nanosystems for on‐demand drug delivery to the GI tract.

中文翻译：

---

活性氧响应纳米平台作为胃肠道靶向的智能给药系统

胃肠道 (GI) 疾病（如炎症性肠病）的药物治疗在靶向功效方面继续面临挑战。对胃肠道发炎区域最大局部药物暴露的需要导致研究重点关注疾病靶向药物递送方法。响应集中在发炎区域的活性氧 (ROS) 的智能纳米材料可以配制成纳米平台，以选择性地释放活性化合物，避免非特异性药物输送到健康组织并限制全身吸收。ROS 响应纳米平台的最新发展包括与其他材料结合以获得多响应系统和修饰/衍生化以增加与生物组织、细胞摄取和靶向的相互作用。