Background: Free radicals lead to destruction in various organs of the organism. The improper use of antibiotics increases the formation of free radicals and causes oxidative stress.

Objective: In this study, it was aimed to determine the effects of gentamicin, amoxicillin, and cefazolin antibiotics on the mouse heart.

Methods: 20 male mice were divided into 4 groups (1st control, 2nd amoxicillin, 3rd cefazolin, and 4th gentamicin groups). The mice in the experimental groups were administered antibiotics intraperitoneally at a dose of 100 mg / kg for 6 days. The control group received normal saline in the same way. The gene expression levels and enzyme activities of SOD, CAT, GPx, GR, GST, and G6PD antioxidant enzymes were investigated.

Results: GSH levels decreased in both the amoxicillin and cefazolin groups, while GR, CAT, and SOD enzyme activities increased. In the amoxicillin group, Gr, Gst, Cat, and Sod gene expression levels increased.

Conclusion: As a result, it was concluded that amoxicillin and cefazolin caused oxidative stress in the heart, however, gentamicin did not cause any effects.

背景：自由基导致生物体各个器官的破坏。抗生素使用不当会增加自由基的形成并引起氧化应激。

目的：本研究旨在确定庆大霉素，阿莫西林和头孢唑林抗生素对小鼠心脏的影响。

方法：将20只雄性小鼠分为4组（第1对照组，第2阿莫西林，第3头孢唑啉和第4庆大霉素组）。实验组的小鼠以100mg / kg的剂量腹膜内给予抗生素6天。对照组以相同方式接受生理盐水。研究了SOD，CAT，GPx，GR，GST和G6PD抗氧化酶的基因表达水平和酶活性。

结果：阿莫西林和头孢唑林组的谷胱甘肽水平降低，而GR，CAT和SOD酶活性增加。在阿莫西林组中，Gr，Gst，Cat和Sod基因表达水平增加。

结论：结论是阿莫西林和头孢唑林可引起心脏氧化应激，而庆大霉素则无任何作用。