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Shining a light on defective autophagy by proteomics approaches: implications for neurodegenerative illnesses.
Expert Review of Proteomics ( IF 3.4 ) Pub Date : 2019-11-14 , DOI: 10.1080/14789450.2019.1691919
Fabio Di Domenico 1 , Ilaria Zuliani 1 , Antonella Tramutola 1
Affiliation  

Introduction: Autophagy is one of the most conserved clearance systems through which eukaryotes manage to handle dysfunctional and excess organelles and macromolecules. This catabolic process has not only a role in the maintenance of basal turnover of cellular components, but it is also essential in cells adaptation to stress conditions. In the last decades, defects in autophagic machinery have been identified as a feature in neurodegenerative diseases. In this context, mass spectrometry-based proteomics has become an important tool in the comprehensive analysis of proteins involved in the autophagic flux.

Area covered: In this review, we discuss recent contributions of proteomic techniques in the study of defective autophagy related to neurodegenerative illness. Particular emphasis is given to the identification of i) shared autophagic markers between different disorders, which support common pathological mechanisms; ii) unique autophagic signature, which could aid to discriminate among diseases.

Expert opinion: Proteomic approaches are valuable in the identification of alterations of components to the autophagic process at different steps of the process. The investigation of autophagic defects associated with neurological disorders is crucial in order to unravel all the potential mechanism leading to neurodegeneration and propose effective therapeutic strategies targeting autophagy.



中文翻译:

通过蛋白质组学方法揭示缺陷性自噬的可能性:对神经退行性疾病的影响。

简介:自噬是最保守的清除系统之一,通过该系统,真核生物可处理功能失调的细胞器和过量的大分子。该分解代谢过程不仅在维持细胞成分的基础周转中起作用,而且在细胞适应应激条件中也是必不可少的。在过去的几十年中,自噬机制的缺陷已被确定为神经退行性疾病的特征。在这种情况下,基于质谱的蛋白质组学已成为对自噬通量涉及的蛋白质进行综合分析的重要工具。

涵盖的领域:在本文中,我们讨论了蛋白质组学技术在与神经退行性疾病相关的自噬缺陷研究中的最新贡献。i)识别不同疾病之间共享的自噬标记物,这些标记物支持常见的病理机制;ii)独特的自噬签名,可帮助区分疾病。

专家意见:蛋白质组学方法在识别自噬过程中各个步骤的组成变化方面非常有价值。与神经系统疾病相关的自噬缺陷的研究对于弄清导致神经退行性变的所有潜在机制并提出针对自噬的有效治疗策略至关重要。

更新日期:2019-11-14
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