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Dopamine D2 Receptor Occupancy Estimated From Plasma Concentrations of Four Different Antipsychotics and the Subjective Experience of Physical and Mental Well-Being in Schizophrenia: Results From the Randomized NeSSy Trial.
Journal of Clinical Psychopharmacology ( IF 2.9 ) Pub Date : 2019-11-7 , DOI: 10.1097/jcp.0000000000001131
Tanja Veselinović 1 , Martin Scharpenberg 2 , Martin Heinze 3 , Joachim Cordes 4 , Bernd Mühlbauer 2, 5 , Georg Juckel 6 , Eckart Rüther 7 , Michael Paulzen 1, 8 , Ekkehard Haen 9 , Christoph Hiemke 10 , Jürgen Timm 2 , Gerhard Gründer 11 ,
Affiliation  

Impaired subjective well-being in schizophrenia patients treated with antipsychotics has often been linked inter alia to the antidopaminergic effects of medication. Thus, it is important to capture the association between striatal dopamine D2 receptor occupancy (D2-RO) and global subjective well-being. We examined this association using data from our multicenter, randomized, double-blind Neuroleptic Strategy Study (NeSSy).

中文翻译:

根据精神分裂症的四种不同抗精神病药的血浆浓度和主观身心健康状况估算的多巴胺D2受体占有率:来自随机NeSSy试验的结果。

抗精神病药治疗的精神分裂症患者的主观幸福感通常与药物的抗多巴胺能作用有关。因此,重要的是要捕捉纹状体多巴胺D2受体占有率(D2-RO)与整体主观幸福感之间的关联。我们使用来自我们的多中心,随机,双盲抗精神病策略研究(NeSSy)的数据检查了这种关联。
更新日期:2020-12-17
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