The combination of olanzapine and valproic acid (VPA) is regularly prescribed in the treatment of bipolar or schizoaffective disorders. The VPA has been shown to reduce olanzapine concentration, but the mechanism behind this interaction remains unknown. We aimed to investigate the effect of VPA on olanzapine concentration during oral versus long-acting injectable (LAI) formulation in a real-life setting.

中文翻译：

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丙戊酸对奥氮平血清浓度的影响：一项研究包括2791例奥氮平片或长效注射剂治疗的患者。

奥氮平和丙戊酸（VPA）的组合在双相或精神分裂性情感障碍的治疗中定期开处方。VPA已显示可降低奥氮平浓度，但这种相互作用背后的机制仍然未知。我们的目的是在现实生活中研究口服VPA和长效注射（LAI）制剂期间VPA对奥氮平浓度的影响。