Introduction: Epidemiologic trends for IPD have evolved with the introduction of pneumococcal conjugate vaccines into childhood immunization programs. We document the ongoing impact of PCV programs in 15 Western European countries.Areas covered: Data were collected from relevant published observational studies and national surveillance websites from January 2010 through January 2018. In countries using PCV13, the proportion of IPD due to PCV13 serotypes declined significantly (from 60-78% to 8-26%) in children <5 years of age within 5-8 years following vaccine introduction. In countries using PCV10, a marked decrease in PCV10-serotype IPD was reported; however, the proportion of IPD due to PCV13 serotypes remained high at 58-64%, predominantly due to serotypes 19A and 3.Expert opinion: The prevalence of vaccine-type IPD in adults remained high; emerging non-vaccine serotypes such as 8, 12F, 22F, 33F, and 15B/C should be a focus of future vaccine development.

中文翻译：

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西欧的血清型进化：关于侵袭性肺炎球菌疾病（IPD）的观点。

简介：IPD的流行病学趋势已经随着将肺炎球菌结合疫苗引入儿童免疫计划而发展。我们记录了PCV计划对15个西欧国家的持续影响。涵盖的范围：数据是从2010年1月至2018年1月从相关发表的观察研究和国家监视网站收集的。在使用PCV13的国家中，由于PCV13血清型引起的IPD比例下降接种疫苗后5-8岁内<5岁的儿童有显着性（从60-78％到8-26％）。据报道，在使用PCV10的国家中，PCV10血清型IPD显着下降。然而，由于PCV13血清型引起的IPD比例仍然很高，为58-64％，主要是由于19A和3血清型引起的。专家意见：成年人中疫苗型IPD的患病率仍然很高；