The microcephaly protein, Cep215, contributes to the engagement of duplicated centrioles in interphase. Now two distinct pools of Cep215 at centrosomes are identified, one bound to Cep68 and the other to pericentrin. Plk1-mediated degradation of Cep68 and separase-mediated cleavage of pericentrin release both pools of Cep215, thereby promoting centriole disengagement.

中文翻译：

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解决中心粒脱离难题。

小头畸形蛋白 Cep215 有助于间期重复中心粒的参与。现在确定了中心体上两个不同的 Cep215 池，一个与 Cep68 结合，另一个与pericentrin 结合。Plk1 介导的 Cep68 降解和分离酶介导的pericentrin 裂解释放两个 Cep215 池，从而促进中心粒脱离。