The prognostic value of the immune cell infiltrate in the breast carcinoma microenvironment is still uncertain. We reviewed published articles analysing the infiltration of inflammatorycells in the microenvironment of breast carcinoma. Data revealed the importance of infiltration of these immune cells in the prognosis of breast carcinoma, particularly the triple-negative and HER2-positive phenotypes. Tumour-infiltrating lymphocytes and their subtypes play a fundamental role in predicting the pathological complete response (pCR) to neoadjuvant chemotherapy. More research aiming to dissect a complex network of communication between cancer cells and other cellular components of the tumour microenvironment is necessary to develop more effective therapeutic approaches.

中文翻译：

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乳腺癌的免疫微环境：新辅助治疗中的预测和预后作用

免疫细胞浸润在乳腺癌微环境中的预后价值仍不确定。我们回顾了已发表的分析乳腺癌微环境中炎症细胞浸润的文章。数据揭示了这些免疫细胞浸润在乳腺癌预后中的重要性，尤其是三阴性和 HER2 阳性表型。肿瘤浸润淋巴细胞及其亚型在预测新辅助化疗的病理完全反应 (pCR) 方面发挥着重要作用。更多旨在剖析癌细胞与肿瘤微环境其他细胞成分之间复杂通讯网络的研究对于开发更有效的治疗方法是必要的。