Antimicrobial peptides (AMPs) or host defense peptides (HDPs) are vital components of human innate defense system targeting human‐related bacteria. Many bacteria have various mechanisms interfering with AMP activity, causing resistance to AMPs. Since AMPs are considered as potential novel antimicrobial drugs, understanding the mechanisms of bacterial resistance to direct killing of AMPs is of great significance. In this review, a comparative overview of bacterial strategies for resistance to direct killing of various AMPs is presented. Such strategies include bacterial cell envelope modification, AMP degradation, sequestration, expelling, and capsule.

中文翻译：

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细菌对抗菌肽的抵抗力。

抗菌肽（AMP）或宿主防御肽（HDP）是针对人类相关细菌的人类先天防御系统的重要组成部分。许多细菌具有多种干扰AMP活性的机制，从而引起对AMP的抗性。由于AMPs被认为是潜在的新型抗菌药物，因此了解细菌对AMPs直接杀灭的耐药性机制具有重要意义。在这篇综述中，提供了对直接杀死各种AMPs的细菌策略的比较概述。这些策略包括细菌细胞包膜修饰，AMP降解，螯合，驱逐和包膜。