Protein design is a valuable tool to create bespoke proteins with desired properties as well as for investigating sequence, structure and function relationships. Membrane protein design is a burgeoning field that is hampered by the lack of high-resolution structural information. In spite of these shortcomings, computational methods have offered a route towards blueprints for these hydrophobic proteins. Advances in structural scoring and sampling methods are enabling more accurate predictions of a folded structure from the primary amino acid sequence. This review highlights a number of novel studies focusing on the methods and information used to successfully design membrane proteins.

中文翻译：

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偶然或设计的膜蛋白。

蛋白质设计是创建具有所需特性的定制蛋白质以及研究序列、结构和功能关系的宝贵工具。膜蛋白设计是一个新兴领域，由于缺乏高分辨率结构信息而受到阻碍。尽管存在这些缺点，但计算方法为这些疏水蛋白的蓝图提供了一条途径。结构评分和采样方法的进步使得从一级氨基酸序列中更准确地预测折叠结构成为可能。这篇综述重点介绍了一些专注于成功设计膜蛋白的方法和信息的新研究。