PURPOSE Myxoma-related intracranial diseases were rarely documented in history. The main purpose of our study is to provide a more comprehensive and detailed understanding of the pathogenesis, imaging features, surgical procedures and pathology of such patients through long-term follow-up. METHODS From March 2012 to July 2018, baseline information that included neuroimaging and neuropathology data from 12 cardiac myxoma patients with neurological symptoms were retrospectively analysed, and the treatment options were discussed. Nine patients underwent long-term postoperative follow-up. RESULTS Twelve cardiac myxoma patients with neurological symptoms were identified, and among them, 10 patients were postoperative patients who had undergone excision of cardiac myxoma, 5 patients had received craniotomy, and the others had received conservative treatment. Positive neuroimaging findings were found in all patients, including cerebral infarction (12/12, 100%), multiple intracranial aneurysms (8/12, 67%), and extravascular metastasis (6/12, 50%). After a long-term average follow-up of 27 months, an increased number of metastatic lesions or an enlargement of the intracranial aneurysms was found in 4 patients. CONCLUSIONS Neuroimaging findings of myxoma-related intracranial lesions were diversed and usually presented as multiple cerebral infarction, aneurysm formation, focal intracranial haemorrhage and space-occupying lesions. Progress is over a long period of time after primary tumour resection. It is necessary for patients to be regularly examined within 2 years after cardiac myxoma resection using MRI+CTA/MRA/DSA in order to be ruled out. Stable and effective chemotherapy drugs are urgently needed.

中文翻译：

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粘液瘤相关颅内疾病的神经影像学特征和长期预后。

目的粘液瘤相关的颅内疾病在历史上鲜有记载。我们研究的主要目的是通过长期随访，对此类患者的发病机理，影像学特征，手术程序和病理学提供更全面，详细的了解。方法回顾性分析2012年3月至2018年7月来自12例具有神经系统症状的心脏粘液瘤患者的神经影像学和神经病理学数据，并讨论了治疗方案。9例患者接受了长期的术后随访。结果确定了12例具有神经系统症状的cardiac门粘液瘤患者，其中10例为术后切除了心脏粘液瘤的患者，5例行了开颅手术，其他人则接受了保守治疗。在所有患者中发现了积极的神经影像学发现，包括脑梗死（12 / 12，100％），多发颅内动脉瘤（8 / 12，67％）和血管外转移（6 / 12，50％）。长期平均随访27个月后，发现4例患者的转移性病变数量增加或颅内动脉瘤增大。结论粘液瘤相关颅内病变的神经影像学表现各不相同，通常表现为多发性脑梗死，动脉瘤形成，局灶性颅内出血和占位性病变。原发肿瘤切除后的进展很长一段时间。为了排除患者，有必要在心脏粘液瘤切除后的2年内使用MRI + CTA / MRA / DSA对患者进行定期检查。