PURPOSE Polycystic ovarian syndrome (PCOS) is one of the most common metabolic and endocrine disorders. Functional foods like pomegranate and probiotics are those that are considered to have beneficial effects on metabolic diseases beyond their basic nutritional value. So, we aimed to evaluate the effect of synbiotic pomegranate juice (SPJ) on cardiovascular risk factors on PCOS patients. METHODS This was a randomized, triple-blinded, 8-week trial. Participants were randomly assigned to receive 300 mL/day of pomegranate juice (PJ), synbiotic beverage (SB), synbiotic pomegranate juice (SPJ), or placebo beverage (PB). Biochemical indices (lipid profile, Total Antioxidant Capacity (TAC), Malondialdehyde (MDA), high sensitive C-Reactive Protein (hs-CRP)) and blood pressure were assessed before and after the intervention. RESULTS Participants in the PJ, SB, and SPJ groups experienced improvement in their lipid profile, oxidative stress, inflammation, and blood pressure during the time. Compared to placebo, Total Cholesterol (TC) was lower in the SB group (P < 0.01), LDL-c was lower in the SPJ and SB groups (P < 0.01), and HDL-c was higher in the SPJ and PJ groups (P < 0.01). With regards to oxidative stress and inflammation, when compared with placebo, MDA was lower in the SPJ, SB, and PJ groups (P < 0.001), TAC was increased in the SPJ and PJ groups (P[Formula: see text] 0.001), and hs-CRP was decreased in the PJ group (P = 0.02). Blood pressure (BP) was lower in the SPJ and PJ groups compared to placebo (P < 0.001; P < 0.01, respectively). CONCLUSIONS Consuming daily SPJ for 8 weeks improved metabolic, oxidative, inflammatory, and BP outcomes in females with PCOS. This trial was registered in the Iranian Registry of Clinical Trials (IRCT20170207032439N2).

中文翻译：

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合生元石榴汁对 PCOS 患者心血管危险因素的影响：一项随机、三盲、对照试验。

目的 多囊卵巢综合征 (PCOS) 是最常见的代谢和内分泌疾病之一。石榴和益生菌等功能性食品被认为对代谢疾病具有超出其基本营养价值的有益作用。因此，我们旨在评估合生元石榴汁 (SPJ) 对 PCOS 患者心血管危险因素的影响。方法 这是一项随机、三盲、为期 8 周的试验。参与者被随机分配接受 300 毫升/天的石榴汁 (PJ)、合生元饮料 (SB)、合生元石榴汁 (SPJ) 或安慰剂饮料 (PB)。在干预前后评估生化指标（脂质谱、总抗氧化能力（TAC）、丙二醛（MDA）、高敏C反应蛋白（hs-CRP））和血压。结果 PJ、SB 和 SPJ 组的参与者在此期间的血脂、氧化应激、炎症和血压都有所改善。与安慰剂相比，SB 组的总胆固醇（TC）较低（P < 0.01），SPJ 和 SB 组的 LDL-c 较低（P < 0.01），SPJ 和 PJ 组的 HDL-c 较高(P < 0.01)。在氧化应激和炎症方面，与安慰剂相比，SPJ、SB 和 PJ 组的 MDA 较低（P < 0.001），SPJ 和 PJ 组的 TAC 增加（P[公式：见正文] 0.001） , PJ 组 hs-CRP 降低 (P = 0.02)。与安慰剂组相比，SPJ 组和 PJ 组的血压 (BP) 较低（分别为 P < 0.001；P < 0.01）。结论 每天服用 SPJ 8 周可改善代谢、氧化、炎症、和多囊卵巢综合征女性的血压结果。该试验已在伊朗临床试验注册中心 (IRCT20170207032439N2) 注册。