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Polyneuropathy and the sural/radial sensory nerve action potential ratio in primary Sjögren's syndrome.
Neurological Research ( IF 1.9 ) Pub Date : 2019-10-29 , DOI: 10.1080/01616412.2019.1680126
Yasemin Eren 1 , Nese Gungor Yavasoglu 1 , Cem Ozisler 2
Affiliation  

Objectives: Polyneuropathy is the most common neurological complication in primary Sjögren's syndrome (pSS). A ratio of sural nerve and superficial radial nerve sensorial action potential amplitudes (SRARs) of <0.4 is an indicator for early axonal neuropathy. We evaluated the polyneuropathies and SRARs in pSS patients.Method: Fifty-two female patients who were diagnosed with pSS according to the European-American Consensus Criteria and 45 healthy controls were enrolled. Nerve conduction studies were performed to diagnose polyneuropathy. Sensory axonal polyneuropathy was diagnosed in three patients, so SRARs were compared in 49 patients and 50 healthy controls.Results: Fifty-two patients with pSS underwent nerve conduction tests. The sural sensory nerve action potential (SNAP) was <6 µV in threepatients and they were diagnosed with sensory axonal neuropathy. SRARs were evaluated in 49 female patients, with a mean age of 51.98 ± 10.79 years and 50 healthy controls with a mean age of 50.52 ± 12.55 years. The mean disease duration was 7.59 ± 6.17 years. The SRAR values were different between the patient and control groups. SRAR was <0.4 in 20.4% of the patient group and <0.4 in 6% of the control group. The SRAR value was not statistically different within the patient group based on anti-Ro and anti-La.Discussion: The potential for neurological involvement in patients with pSS who have no signs or injury should be evaluated because nervous system involvement in pSS is a negative prognostic factor. SRAR in patients with pSS can be used as a marker for the early detection of axonal neuropathy.

中文翻译:

多发性神经病和原发性干燥综合征的腓肠神经/ radi神经感觉神经动作电位比。

目的:多发性神经病是原发性干燥综合征(pSS)中最常见的神经系统并发症。腓肠神经与radial神经浅表感觉动作电位振幅(SRARs)之比<0.4是早期轴突神经病的指标。我们评估了pSS患者的多发性神经病和SRAR。方法:根据欧洲共识标准诊断为pSS的52例女性患者和45名健康对照者。进行了神经传导研究以诊断多发性神经病。结果:3例患者诊断为感觉轴突性多发性神经病,因此对49例患者和50例健康对照者进行了SRAR比较。结果:52例pSS患者接受了神经传导测试。腓肠感觉神经动作电位(SNAP)< 在三名患者中为6 µV,他们被诊断为感觉轴突神经病。在49位平均年龄为51.98±10.79岁的女性患者和50位平均年龄为50.52±12.55岁的健康对照组中评估了SRAR。平均病程为7.59±6.17年。患者和对照组之间的SRAR值不同。在20.4%的患者组中SRAR <0.4,在对照组的6%中<0.4。讨论:基于抗Ro和抗La的患者组中SRAR值在统计学上无差异。讨论:应评估无体征或损伤的pSS患者神经系统受累的可能性,因为pSS的神经系统受累为阴性预后因素。pSS患者中的SRAR可用作早期检测轴突神经病的标志物。在49位平均年龄为51.98±10.79岁的女性患者和50位平均年龄为50.52±12.55岁的健康对照组中评估了SRAR。平均病程为7.59±6.17年。患者和对照组之间的SRAR值不同。在20.4%的患者组中SRAR <0.4,在对照组的6%中<0.4。讨论:基于抗Ro和抗La的患者组中SRAR值在统计学上无差异。讨论:应评估无体征或损伤的pSS患者神经系统受累的可能性,因为pSS的神经系统受累为阴性预后因素。pSS患者中的SRAR可用作早期检测轴突神经病的标志物。在49位平均年龄为51.98±10.79岁的女性患者和50位平均年龄为50.52±12.55岁的健康对照组中评估了SRAR。平均病程为7.59±6.17年。患者和对照组之间的SRAR值不同。在20.4%的患者组中SRAR <0.4,在对照组的6%中<0.4。讨论:基于抗Ro和抗La的患者组中SRAR值在统计学上无差异。讨论:应评估无体征或损伤的pSS患者神经系统受累的可能性,因为pSS的神经系统受累为阴性预后因素。pSS患者中的SRAR可用作早期检测轴突神经病的标志物。79岁和50名健康对照者,平均年龄为50.52±12.55岁。平均病程为7.59±6.17年。患者和对照组之间的SRAR值不同。在20.4%的患者组中SRAR <0.4,在对照组的6%中<0.4。讨论:基于抗Ro和抗La的患者组中SRAR值在统计学上无差异。讨论:应评估无体征或损伤的pSS患者神经系统受累的可能性,因为pSS的神经系统受累为阴性预后因素。pSS患者中的SRAR可用作早期检测轴突神经病的标志物。79岁和50名健康对照者,平均年龄为50.52±12.55岁。平均病程为7.59±6.17年。患者和对照组之间的SRAR值不同。在20.4%的患者组中SRAR <0.4,在对照组的6%中<0.4。讨论:基于抗Ro和抗La的患者组中SRAR值在统计学上无差异。讨论:应评估无体征或损伤的pSS患者神经系统受累的可能性,因为pSS的神经系统受累为阴性预后因素。pSS患者中的SRAR可用作早期检测轴突神经病的标志物。患者组为4%,对照组为6%,<0.4。讨论:基于抗Ro和抗La的患者组中SRAR值在统计学上无差异。讨论:应评估无体征或损伤的pSS患者神经系统受累的可能性,因为pSS的神经系统受累为阴性预后因素。pSS患者中的SRAR可用作早期检测轴突神经病的标志物。患者组为4%,对照组为6%,<0.4。讨论:基于抗Ro和抗La的患者组中SRAR值在统计学上无差异。讨论:应评估无体征或损伤的pSS患者神经系统受累的可能性,因为pSS的神经系统受累为阴性预后因素。pSS患者中的SRAR可用作早期检测轴突神经病的标志物。
更新日期:2019-11-01
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