IGF-I and IGFBPs have important physiological modulatory effects and this study sought to examine the influence of active vs. passive recovery following a heavy resistance exercise on IGF-I and IGF binding protein (IGFBP) recovery responses. It was hypothesized that increased IGF-I and decreased inhibitory IGFBPs during active recovery may be reflective of cascades promoting physiological recovery. 18 untrained men ((AR n = 7, PR n = 11), age: 26 ± 4 years, height: 174 ± 8 cm, body mass: 75 ± 13 kg) performed either a protocol-specific 10 × 10 × 30% 1RM active (AR) or passive recovery (PR) session following a heavy resistance exercise session performed on a leg press device (10 × 10 1RM). Maximal isometric force production (MVC) and IGF- and IGFBPs were measured pre, post, 1-hr post, and next morning. A significantly greater relative response in IGF-I was observed in AR than in PR at post recovery and next morning (p < .01 and statistical trend, respectively) while absolute concentrations of IGFBP-1 at next morning were significantly higher in PR than AR (p < .05), and relative IGFBP-1 response from control to next morning in PR was significantly greater than in AR (p < .001). IGFBP-1 may be inhibitory to IGF-I biological action, thus the lower concentration of IGFBP-1 after AR may be considered favorable in terms of recovery due to its positive relationship with glucose metabolism and maintaining metabolic homeostasis. These results suggest that some of the benefits of an active recovery bout may be mediated by favorable IGF-I system responses (increased IGF-I and decreased IGFBP-1) in the hormonal milieu that may assist facilitating the cascade of physiological recovery processes following acute heavy resistance loading exercise.

IGF-I和IGFBP具有重要的生理调节作用，本研究试图研究重度抵抗运动后主动恢复与被动恢复对IGF-1和IGF结合蛋白（IGFBP）恢复反应的影响。假设在主动恢复期间增加的IGF-I和减少的抑制性IGFBP可能反映了促进生理恢复的级联反应。18名未经训练的人（（AR n  = 7，PR n = 11），年龄：26±4岁，身高：174±8 cm，体重：75±13 kg）执行特定于协议的10×10×30％1RM主动（AR）或被动恢复（PR）阶段在腿部推举器械（10×10 1RM）上进行重阻力训练之后。在赛前，赛后，赛后1小时和第二天早晨测量最大等距力产生（MVC）以及IGF-和IGFBP。恢复后和第二天早上，AR中IGF-I的相对反应明显高于PR（分别为p  <.01和统计趋势），而第二天早上，IGFBP-1的绝对浓度则明显高于AR （p  <.05），而从对照组到第二天早晨，IGRBP-1的相对反应显着大于AR（p <.001）。IGFBP-1可能抑制IGF-I的生物学作用，因此AR后IGFBP-1的较低浓度由于其与葡萄糖代谢和维持代谢稳态的正相关而在恢复方面被认为是有利的。这些结果表明，激素环境中有利的IGF-I系统反应（IGF-I升高和IGFBP-1降低）可以介导主动恢复发作的某些益处，这可能有助于促进急性后的生理恢复过程的级联重阻力负荷运动。