In a recent Editorial, De Schutter commented on our recent study on the roles of a cortico-cerebellar loop in motor planning in mice (De Schutter 2019, Neuroinformatics, 17, 181–183, Gao et al. 2018, Nature, 563, 113–116). Two issues were raised. First, De Schutter questions the involvement of the fastigial nucleus in motor planning, rather than the dentate nucleus, given previous anatomical studies in non-human primates. Second, De Schutter suggests that our study design did not delineate different components of the behavior and the fastigial nucleus might play roles in sensory discrimination rather than motor planning. These comments are based on anatomical studies in other species and homology-based arguments and ignore key anatomical data and neurophysiological experiments from our study. Here we outline our interpretation of existing data and point out gaps in knowledge where future studies are needed.

中文翻译：

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对“老鼠实验的狂热”的回应。

在最近的社论中，De Schutter评论了我们最近关于皮质小脑环在小鼠运动计划中的作用的研究（De Schutter 2019，Neuroinformatics，17，181–183，Gao et al。2018，Nature，563，113–116）。提出了两个问题。首先，鉴于先前在非人类灵长类动物中进行的解剖学研究，德舒特质疑小脑顶核是否参与了运动计划，而不是齿状核。其次，德舒特（De Schutter）提出，我们的研究设计并未描述行为的不同组成部分，而小脑顶核可能在感觉辨别而非运动计划中起作用。这些评论基于其他物种的解剖学研究和基于同源性的论点，而忽略了我们研究中的关键解剖学数据和神经生理学实验。在这里，我们概述了对现有数据的解释，并指出了需要进一步研究的知识空白。