The objective of the study is to establish exposure-excretion relationship between dichlorometane (DCM) in air (DCM-A) and in urine (DCM-U) in workplace to confirm a previous report. Male workers in a screen-printing plant participated in the study. Time-weighted average DCM-A was measured by diffusive sampling followed by gas-chromatography (GC), and DCM in end-of-shift urine samples was by head-space GC. The data were subjected to regression and other statistical analyses. In practice, 30 sets of DCM-A and DCM-U values were available. The geometric mean DCM-A was 8.4 ppm and that of DCM-U (as observed) was 41.1 µg/l. The correlation coefficients (0.70-0.85) were statistically significant across the correction for urine density. Thus, the analysis for un-metabolized DCM in end-of-shift urine samples is applicable for biological monitoring of occupational exposure to DCM, in support of and in agreement with the previous report. In conclusion, biological monitoring of occupational DCM exposure is possible by use of analysis for un-metabolized DCM in end-of-shift urine.

中文翻译：

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通过尿液分析未代谢的二氯甲烷对职业性接触二氯甲烷的生物学监测。

这项研究的目的是建立工作场所空气中（DCM-A）和尿液（DCM-U）中的二氯甲烷（DCM）的暴露-排泄关系，以确认以前的报告。丝网印刷厂的男性工人参加了这项研究。时间加权平均DCM-A通过扩散采样，然后进行气相色谱（GC）进行测量，而班次结束尿液样本中的DCM通过顶空GC进行测量。对数据进行回归分析和其他统计分析。实际上，有30套DCM-A和DCM-U值可用。DCM-A的几何平均数为8.4 ppm，而DCM-U的几何平均数为41.1 µg / l。在校正尿液密度的过程中，相关系数（0.70-0.85）在统计学上显着。从而，轮班结束时尿液样品中未代谢的DCM的分析可用于对职业接触DCM的生物进行生物学监测，以支持并同意上一份报告。总之，可以通过对轮班结束时尿中未代谢的DCM进行分析来对职业DCM暴露进行生物学监测。