Human aging affects the entire organism, but aging of the brain must undoubtedly be different from that of all other organs, as neurons are highly differentiated postmitotic cells, for the majority of which the lifespan in the postnatal period is equal to the lifespan of the entire organism. In this work, we examine the distinctive features of brain aging and neurogenesis during normal aging, pathological aging (Alzheimer’s disease), and accelerated aging (Hutchinson-Gilford progeria syndrome and Werner syndrome).

中文翻译：

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神经发生和大脑老化

人的衰老影响整个机体，但大脑的衰老无疑与其他器官的衰老不同，因为神经元是高度分化的有丝分裂后细胞，其中大部分在出生后的寿命等于整个器官的寿命。生物。在这项工作中，我们检查了正常衰老、病理性衰老（阿尔茨海默病）和加速衰老（Hutchinson-Gilford 早衰综合征和 Werner 综合征）期间大脑衰老和神经发生的独特特征。