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Human developmental exposure to endocrine active compounds.
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2002-09-01 , DOI: 10.1016/s1382-6689(02)00025-x
Warren G Foster 1 , Claude L Hughes , Siu Chan , Lawrence Platt
Affiliation  

Quantification of exposure to environmental contaminants such as endocrine active chemicals (EACs) during critical periods of development, particularly in utero, remains largely unexplored. Therefore, we tested the hypothesis that EACs can be detected and quantified in second trimester human amniotic fluid. Amniotic fluid was obtained from women (n=175) undergoing routine amniocentesis between 14 and 21 weeks gestation. Samples were assayed by gas chromatography/mass spectrometry (GC/MS) for common organochlorine contaminants and dietary phytoestrogens. The DDT metabolite p,p'-DDE was found in approximately 25% of amniotic fluid samples (mean±S.D., 0.15±0.06 ng/ml) whereas the dietary phytoestrogens, genistein and or daidzein were found in 96.2% of samples tested (0.94±0.91 and 1.08±0.91 ng/ml, respectively). Our results demonstrate that: (1) human amniotic fluid is a suitable biological medium to evaluate developmental exposure to EACs, and (2) fetuses are exposed to biologically active levels of EACs in mid pregnancy.

中文翻译:

人类发育暴露于内分泌活性化合物。

在发育的关键时期,特别是在子宫内,对环境污染物(例如内分泌活性化学物质(EAC))的暴露量的量化仍未开发。因此,我们检验了在妊娠中期人羊水中可以检测和定量EAC的假设。羊水来自于在妊娠14到21周之间接受常规羊膜穿刺术的女性(n = 175)。通过气相色谱/质谱(GC / MS)分析样品中常见的有机氯污染物和饮食中的植物雌激素。在约25%的羊水样本中发现DDT代谢物p,p'-DDE(平均值±SD,0.15±0.06 ng / ml),而在饮食的样本中96.3%的人发现饮食中的植物雌激素,染料木黄酮和/或大豆黄酮(0.94分别为±0.91和1.08±0.91 ng / ml)。我们的结果表明:
更新日期:2019-11-01
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