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Glycoside hydrolases in Aplysia fasciata: analysis and applications.
Biotechnology and Genetic Engineering Reviews ( IF 3.2 ) Pub Date : 2008-01-01 , DOI: 10.5661/bger-25-129
Antonio Trincone 1 , Annabella Tramice , Assunta Giordano , Giuseppina Andreotti
Affiliation  

Glycosylation is considered to be an important reaction for the chemical modification of compounds with useful biological activities. Glycoside hydrolases are biotechnologically attractive enzymes which can be used in synthetic reactions for assembling glycosidic linkages with absolute stereoselectivity at an anomeric centre. Most of these enzymes are commercially available but there is great interest in the search for new biocatalysts with original catalytic characteristics. The marine environment has shown to be a very interesting source for new glycosyl hydrolases for both hydrolytic and synthetic aspects. In particular, Aplysia fasciata a marine herbivorous mollusc has been shown to be a potent producer of a library of glycoside hydrolases applied to the synthesis of glycosidic bonds. The impressive assortment of glycosidases in marine organisms clearly indicates that the potential biodiversity of these enzymes is still largely unexplored and that potential applications of biocatalysts from the sea will increase in the near future.

中文翻译:

筋膜中的糖苷水解酶:分析和应用。

糖基化被认为是对具有有用生物活性的化合物进行化学修饰的重要反应。糖苷水解酶是具有生物技术吸引力的酶,可用于合成反应中,在异头中心以绝对立体选择性组装糖苷键。这些酶大多数是可商购的,但是对于寻找具有原始催化特性的新型生物催化剂引起了极大的兴趣。对于水解和合成方面,海洋环境已经显示出是用于新糖基水解酶的非常有趣的来源。特别地,已经证明,海洋草食性软体动物Aplysia fasciata是用于糖苷键合成的糖苷水解酶文库的有效生产者。
更新日期:2019-11-01
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