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Frequencies of killer immunoglobulin-like receptor genotypes influence susceptibility to spontaneous abortion.
Journal of Applied Genetics ( IF 2.4 ) Pub Date : 2009 , DOI: 10.1007/bf03195699 I Nowak 1 , A Malinowski , H Tchorzewski , E Barcz , J R Wilczynski , M Grybos , M Kurpisz , W Luszczek , M Banasik , D Reszczynska-Slezak , E Majorczyk , A Wisniewski , D Senitzer , J Yao Sun , P Kusnierczyk
Journal of Applied Genetics ( IF 2.4 ) Pub Date : 2009 , DOI: 10.1007/bf03195699 I Nowak 1 , A Malinowski , H Tchorzewski , E Barcz , J R Wilczynski , M Grybos , M Kurpisz , W Luszczek , M Banasik , D Reszczynska-Slezak , E Majorczyk , A Wisniewski , D Senitzer , J Yao Sun , P Kusnierczyk
Affiliation
Natural killer (NK) cells are the most abundant lymphocyte population in the decidua. These cells express killer immunoglobulin-like receptors (KIRs), which upon recognition of HLA class I molecules on trophoblasts may either stimulate NK cells (activating KIRs) or inhibit them (inhibitory KIRs) to produce soluble factors necessary for the maintenance of pregnancy.KIR genes exhibit extensive haplotype polymorphism; individuals differ in both the number and kind (activating vs. inhibitory) ofKIR genes. This polymorphism affects NK cell reactivity and susceptibility to diseases, including gynecological disorders. Therefore weKIR-genotyped 149 spontaneously aborting women and 117 control multiparae (at least 2 healthy-born children). Several genotypes (i.e. combinations of variousKIR genes) were differently distributed among the patients and control subjects. Differences were observed in the numbers and the ratios of activating to inhibitory KIRs between patients and healthy women: (i) genotypes containing 6 activatingKIR genes were less frequent and those containing 6 inhibitoryKIR genes were more frequent in patients than in control subjects, and (ii) an excess of inhibitory KIRs (activating-to-inhibitoryKIR gene ratios of 0.33 to 0.83) was associated with miscarriage, whereas ratios close to equilibrium (0.86–1.25) seemed to be protective. In addition, the results suggest for the first time that sporadic and recurrent spontaneous abortions as well as miscarriage in the presence or absence of autoantibodies may have differentKIR genotypic backgrounds.
中文翻译:
杀伤性免疫球蛋白样受体基因型的频率影响自然流产的易感性。
自然杀伤 (NK) 细胞是蜕膜中最丰富的淋巴细胞群。这些细胞表达杀伤性免疫球蛋白样受体 (KIR),在识别滋养层细胞上的 HLA I 类分子后,它们可以刺激 NK 细胞(激活 KIR)或抑制它们(抑制性 KIR)以产生维持妊娠所必需的可溶性因子。KIR基因表现出广泛的单倍型多态性;个体在KIR基因的数量和种类(激活与抑制)方面存在差异。这种多态性会影响 NK 细胞的反应性和对疾病的易感性,包括妇科疾病。因此我们KIR-基因分型 149 名自然流产妇女和 117 名对照经产妇(至少 2 个健康出生的孩子)。几种基因型(即各种KIR基因的组合)在患者和对照受试者中的分布不同。观察到患者和健康女性之间激活与抑制KIR的数量和比率存在差异:(i)患者中含有 6 个激活KIR基因的基因型频率较低,而含有 6 个抑制性KIR基因的基因型较对照组更频繁,和(ii) 过量的抑制性KIR(激活到抑制性KIR0.33 至 0.83 的基因比率与流产有关,而接近平衡的比率 (0.86–1.25) 似乎具有保护作用。此外,该结果首次表明,在存在或不存在自身抗体的情况下,散发性和复发性自然流产以及流产可能具有不同的KIR基因型背景。
更新日期:2020-09-22
中文翻译:
杀伤性免疫球蛋白样受体基因型的频率影响自然流产的易感性。
自然杀伤 (NK) 细胞是蜕膜中最丰富的淋巴细胞群。这些细胞表达杀伤性免疫球蛋白样受体 (KIR),在识别滋养层细胞上的 HLA I 类分子后,它们可以刺激 NK 细胞(激活 KIR)或抑制它们(抑制性 KIR)以产生维持妊娠所必需的可溶性因子。KIR基因表现出广泛的单倍型多态性;个体在KIR基因的数量和种类(激活与抑制)方面存在差异。这种多态性会影响 NK 细胞的反应性和对疾病的易感性,包括妇科疾病。因此我们KIR-基因分型 149 名自然流产妇女和 117 名对照经产妇(至少 2 个健康出生的孩子)。几种基因型(即各种KIR基因的组合)在患者和对照受试者中的分布不同。观察到患者和健康女性之间激活与抑制KIR的数量和比率存在差异:(i)患者中含有 6 个激活KIR基因的基因型频率较低,而含有 6 个抑制性KIR基因的基因型较对照组更频繁,和(ii) 过量的抑制性KIR(激活到抑制性KIR0.33 至 0.83 的基因比率与流产有关,而接近平衡的比率 (0.86–1.25) 似乎具有保护作用。此外,该结果首次表明,在存在或不存在自身抗体的情况下,散发性和复发性自然流产以及流产可能具有不同的KIR基因型背景。