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Memory profiling in mild cognitive impairment: can we determine risk for Alzheimer's disease?
Journal of Neuropsychology ( IF 2.2 ) Pub Date : 2008-09-01 , DOI: 10.1348/174866407x227015
Kerryn E Pike 1 , Greg Savage
Affiliation  

Mild cognitive impairment (MCI) is considered a transitional stage between normal ageing and Alzheimer's disease (AD), but not all MCI cases progress to AD and there has been limited focus on how to identify who will progress. Given claims for a characteristic kind of memory impairment in AD involving deficits in encoding and consolidation of information, we propose that 'memory profiling' of individuals with MCI may help identify which individuals will progress. We initially set out to establish whether the same characteristic memory profile was present prior to the onset of AD (preAD). Very few studies provided data that allowed us to examine this, but results tentatively supported an encoding/consolidation profile in preAD. A single study tested the clinically important contrast of preAD versus non-preAD MCI cases and found no difference under any condition or in memory profiles, but interpretation of the findings is limited by short duration of follow-up, ceiling effects, and task limitations in assessing more complex and qualitative aspects of memory. Although existing data lead to equivocal conclusions, we believe that memory profiling is an endeavour worth pursuing, particularly given the increasing number of people with MCI presenting for clinical assessment. We propose that tests designed specifically to measure memory processes should be sensitive to preAD and are required in prospective longitudinal designs to identify these clinically crucial MCI cases.

中文翻译:

轻度认知障碍中的记忆分析:我们能否确定阿尔茨海默氏病的风险?

轻度认知障碍(MCI)被认为是正常衰老与阿尔茨海默氏病(AD)之间的过渡阶段,但并非所有MCI病例都可进展为AD,并且对如何确定谁会进展的关注也很有限。考虑到AD的一种典型的记忆障碍,包括信息编码和整合不足,我们建议对MCI患者进行“记忆分析”可以帮助确定哪些患者会进步。我们最初着手确定在AD(preAD)发作之前是否存在相同的特征性内存配置文件。很少有研究提供允许我们检查此数据的数据,但结果暂定支持preAD中的编码/合并配置文件。一项研究测试了preAD与非preAD MCI病例在临床上的重要对比,发现在任何情况下或在记忆特征方面均无差异,但对结果的解释受到随访时间短,上限效应和任务限制的限制。评估记忆的更复杂和定性的方面。尽管现有数据得出模棱两可的结论,但我们认为记忆分析是一项值得追求的工作,特别是考虑到越来越多的MCI患者需要进行临床评估。我们建议专为测量记忆过程而设计的测试应对preAD敏感,并且在前瞻性纵向设计中需要使用这些测试来识别这些临床上至关重要的MCI病例。但是对结果的解释受到随访时间短,上限效应以及评估记忆的更复杂和定性方面的任务限制的限制。尽管现有数据得出模棱两可的结论,但我们认为记忆分析是一项值得追求的工作,特别是考虑到越来越多的MCI患者需要进行临床评估。我们建议专为测量记忆过程而设计的测试应对preAD敏感,并且在前瞻性纵向设计中需要使用这些测试来识别这些临床上至关重要的MCI病例。但是对结果的解释受到随访时间短,上限效应以及评估记忆的更复杂和定性方面的任务限制的限制。尽管现有数据得出模棱两可的结论,但我们认为记忆分析是一项值得追求的工作,特别是考虑到越来越多的MCI患者需要进行临床评估。我们建议专为测量记忆过程而设计的测试应对preAD敏感,并且在前瞻性纵向设计中需要使用这些测试来识别这些临床上至关重要的MCI病例。特别是考虑到越来越多的MCI患者需要进行临床评估。我们建议专为测量记忆过程而设计的测试应对preAD敏感,并且在预期的纵向设计中需要使用这些测试来识别这些临床关键的MCI病例。特别是考虑到越来越多的MCI患者需要进行临床评估。我们建议专为测量记忆过程而设计的测试应对preAD敏感,并且在前瞻性纵向设计中需要使用这些测试来识别这些临床上至关重要的MCI病例。
更新日期:2019-11-01
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