The surface of poly(dimethylsiloxane) (PDMS) is grafted with poly(acrylic acid) (PAA) layers via surface‐initiated photopolymerization to suppress the capsular contracture resulting from a foreign body reaction. Owing to the nature of photo‐induced polymerization, various PAA micropatterns can be fabricated using photolithography. Hole and stripe micropatterns ≈100‐µm wide and 3‐µm thick are grafted onto the PDMS surface without delamination. The incorporation of PAA micropatterns provides not only chemical cues by hydrophilic PAA microdomains but also topographical cues by hole or stripe micropatterns. In vitro studies reveal that a PAA‐grafted PDMS surface has a lower proliferation of both macrophages (Raw 264.7) and fibroblasts (NIH 3T3) regardless of the pattern presence. However, PDMS with PAA micropatterns, especially stripe micropatterns, minimizes the aggregation of fibroblasts and their subsequent differentiation into myofibroblasts. An in vivo study also shows that PDMS samples with stripe micropatterns polarized macrophages into anti‐inflammatory M2 macrophages and most effectively inhibits capsular contracture, which is demonstrated by investigation of inflammation score, transforming‐growth‐factor‐β expression, number of macrophages, and myofibroblasts as well as the collagen density and capsule thickness.

中文翻译：

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通过嫁接不同地形的聚丙烯酸微图案对PDMS植入物异物反应的调节。

聚（二甲基硅氧烷）（PDMS）的表面通过表面引发的光聚合作用与聚（丙烯酸）（PAA）层接枝，以抑制异物反应导致的囊膜挛缩。由于光致聚合的性质，可以使用光刻法制造各种PAA微图案。约100 µm宽且3 µm厚的孔和条纹微图案被嫁接到PDMS表面而不会分层。PAA微图案的结合不仅通过亲水性PAA微域提供化学线索，而且通过孔或条纹微图案提供地形线索。体外研究表明，无论存在哪种模式，PAA移植的PDMS表面均具有较低的巨噬细胞（Raw 264.7）和成纤维细胞（NIH 3T3）增殖。但是，带有PAA微图案，尤其是条纹微图案的PDMS，最小化成纤维细胞的聚集及其随后分化为成肌纤维细胞。一项体内研究还显示，具有条纹微图案的PDMS样品将巨噬细胞极化为抗炎M2巨噬细胞，并且最有效地抑制了囊膜挛缩，这通过研究炎症评分，转化生长因子β表达，巨噬细胞数量和肌成纤维细胞以及胶原蛋白密度和胶囊厚度。