Annual flu led by influenza viruses is contemplated to be one of the foremost global health challenges due to its rapid spread leading to the life-threatening epidemic or pandemic. An enormous number of people die due to flu and its associated intricacies every year. Annual vaccination is considered to be the gold standard strategy to protect the individual from acquiring infection and further decimation, although recent estimates suggest that overall flu vaccine effectiveness was within 19% to 53% in last five years. A significant weakness of current vaccination is its inability to protect an individual from different or mutant flu strain. Host immune system performs a vital role during natural infection or after vaccination leading to influenza-specific immunities. Previous imprints of common flu or vaccination may alter the outcomes of the current vaccination. Current flu vaccine regime does not consider the host immune status before vaccination. Irrespective of the previous influenza exposure history or prior flu vaccination, individual get flu vaccination based on WHO recommendation with selected strains which may be the reason why induction of broad immunities does not transpire with their testimonial. Over the last few decades, scientific research had identified the role of preexisting immunities on vaccination or natural infection outcome. In this review, we are proposing the concept of personalized flu vaccines depending on individual immune status. We will also discuss why individual was unable to induce broader immunities to protect itself from diverse influenza viruses and how we can accomplish that goal with the current findings.

中文翻译：

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当前的挑战：从“原始抗原犯罪”的道路走向通用流感疫苗的开发。

由于流感病毒的迅速传播导致威胁生命的流行病或大流行，因此，由流感病毒引起的年度流感被认为是全球最重要的健康挑战之一。每年都有大量人死于流感及其相关的复杂性。尽管最近的估计表明，过去五年来总体流感疫苗的有效性在19％到53％之内，但是每年接种疫苗被认为是保护个人免于感染和进一步抽血的金标准策略。当前疫苗接种的一个显着弱点是它不能保护个体免受不同或突变的流感病毒株的侵害。宿主免疫系统在自然感染期间或接种疫苗后可发挥特定作用，从而产生针对流感的特异性免疫。以前的普通流感或疫苗接种印记可能会改变当前疫苗接种的结果。当前的流感疫苗接种方案并未考虑疫苗接种前宿主的免疫状况。不论以前有过流感暴露史或以前有过流感疫苗接种，都是根据WHO推荐的选择菌株对患者进行流感疫苗接种，这可能是广泛免疫诱导不能随其证明而有效的原因。在过去的几十年中，科学研究确定了预先存在的免疫对疫苗接种或自然感染结果的作用。在这篇综述中，我们提出了根据个体免疫状况的个性化流感疫苗的概念。