The aim of the study was to investigate the relationship between liver transaminase levels and metabolic syndrome (MS) features in obese children and adolescents. A total of 132 children and adolescents (73 males and 59 females) aged 8–16, participated in the study. All were studied at the department of Paediatrics, University Hospital of Zaragoza (Spain). Inclusion criteria were the existence of obesity as defined by body mass index (BMI) according to Cole cut-off values (when BMI was higher than the age and sex specific equivalent to 30 kg/m²). The definition of metabolic syndrome was according to the International Diabetes Federation criteria. Weight (kg), height (cm), waist circumference (cm), blood pressure and BMI were measured. Laboratory determinations after overnight fasting included: transaminases (ALT, AST, GGT), fasting glucose, insulin, triglycerides and HDL-C. The MS was found in 21.6% of the obese children and adolescents and the prevalence was higher in males (25.9%) than in females (15.9%). Serum transaminases (ALT, AST and GGT) mean concentrations were higher in males than in females, and decreased during pubertal development. The obese children and adolescents with the MS did not show higher transaminases concentrations when compared with those without the MS. Some MS manifestations (mainly waist circumference) showed a correlation with ALT, although all transaminases values were normal according to adult references. Liver transaminases, a surrogate marker of NAFLD, did not show an early and consistent manifestation of abnormalities in the obese children and adolescents studied. In order to define the presence of the disease, it would be necessary to obtain aminotransferase reference standards for children and adolescents, considering pubertal stage and gender.

中文翻译：

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肥胖儿童和青少年的血清转氨酶浓度。

该研究的目的是调查肥胖儿童和青少年肝转氨酶水平与代谢综合征 (MS) 特征之间的关系。共有 132 名 8-16 岁的儿童和青少年（73 名男性和 59 名女性）参与了这项研究。所有人都在萨拉戈萨大学医院（西班牙）儿科进行了研究。纳入标准是根据 Cole 截断值（当 BMI 高于年龄和性别特定相当于 30 kg/m ²时，由体重指数（BMI）定义的肥胖存在）。代谢综合征的定义是根据国际糖尿病联合会的标准。测量体重（kg）、身高（cm）、腰围（cm）、血压和BMI。隔夜禁食后的实验室测定包括：转氨酶（ALT、AST、GGT）、禁食葡萄糖、胰岛素、甘油三酯和 HDL-C。MS 在 21.6% 的肥胖儿童和青少年中被发现，男性 (25.9%) 的患病率高于女性 (15.9%)。男性的血清转氨酶（ALT、AST 和 GGT）平均浓度高于女性，并在青春期发育期间降低。与没有 MS 的肥胖儿童和青少年相比，患有 MS 的肥胖儿童和青少年没有表现出更高的转氨酶浓度。一些 MS 表现（主要是腰围）显示与 ALT 相关，尽管根据成人参考，所有转氨酶值均正常。肝转氨酶是 NAFLD 的替代标志物，在所研究的肥胖儿童和青少年中没有表现出早期和一致的异常表现。为了确定该疾病的存在，考虑到青春期阶段和性别，有必要获得儿童和青少年的转氨酶参考标准。