Fission yeast has two TOR kinases, Tor1 and Tor2. Recent studies have indicated that this microbe has a TSC/Rheb/TOR pathway like higher eukaryotes. Two TOR complexes, namely TORC1 and TORC2, have been identified in this yeast, as in budding yeast and mammals. Fission yeast TORC1, which contains Tor2, and TORC2, which contains Tor1, apparently have opposite functions with regard to the promotion of G1 arrest and sexual development. Rapamycin does not inhibit growth of wild-type fission yeast cells, unlike other eukaryotic cells, but precise analyses have revealed that rapamycin affects certain cellular functions involving TOR in this yeast. It appears that fission yeast has a potential to be an ideal model system to investigate the TOR signaling pathways.

中文翻译：

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裂变酵母中的TOR信号。

裂变酵母具有两个TOR激酶，Tor1和Tor2。最近的研究表明，这种微生物具有像高等真核生物一样的TSC / Rheb / TOR途径。在酵母中已经鉴定出两种TOR复合物，即TORC1和TORC2，如在萌芽的酵母和哺乳动物中。含有Tor2的裂变酵母TORC1和含有Tor1的TORC2显然在促进G1停滞和性发育方面具有相反的功能。与其他真核细胞不同，雷帕霉素不抑制野生型裂变酵母细胞的生长，但是精确的分析显示雷帕霉素会影响该酵母中涉及TOR的某些细​​胞功能。裂变酵母似乎有可能成为研究TOR信号通路的理想模型系统。