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Liposome-Mediated Triggering of Complement Cascade
Journal of Liposome Research ( IF 4.4 ) Pub Date : 2008-01-01 , DOI: 10.1080/08982100802309552
S Moein Moghimi 1 , Islam Hamad
Affiliation  

The complement system is one of the most ancient defense strategies, which serves as an important effector arm of both innate and acquired immunity. Three consequences ensue when liposomes trigger the complement system in the blood. These are priming of the vesicular surface by opsonic complement fragments for recognition and clearance by phagocytic cells, generation of anaphylatoxins, and chemoattractants, which may subsequently initiate pseudoallergy-related anaphylaxis in sensitive individuals, and insertion of the lytic complex C5b-9 into the liposomal bilayer, which may result in substantial leakage of vesicular encapsulated aqueous cargo. Here, we briefly review and discuss the molecular basis of complement activation by phospholipid vesicles and reflect on sensitive and rapid Enzyme-Linked Immunosorbent Assays (ELISA) for assessing and monitoring liposome-mediated triggering of a complement cascade in human serum.

中文翻译:

脂质体介导的补体级联触发

补体系统是最古老的防御策略之一,它是先天免疫和后天免疫的重要效应臂。当脂质体触发血液中的补体系统时,会产生三种后果。这些是由调理性补体片段启动囊泡表面以被吞噬细胞识别和清除,产生过敏毒素和化学引诱物,随后可能在敏感个体中引发与假性过敏相关的过敏反应,以及将裂解复合物 C5b-9 插入脂质体双层,这可能导致囊泡包裹的水性货物大量泄漏。这里,
更新日期:2008-01-01
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