Gamma-polyglutamic acid (gamma-PGA) is a hydrophilic, biodegradable, and naturally available biopolymer produced by a number of microbial species, most commonly, the Bacillaceae family. Its biological properties such as nontoxicity, biocompatibility, and nonimmunogenicity qualify it as an important biomaterial in drug delivery applications. This review focuses mainly on the development of gamma-PGA nanoparticles as drug delivery carriers for anticancer therapeutics. We discuss various techniques for the production and characterization of gamma-PGA nanoparticles and controlled-release strategies. We also present a brief overview of the tumor physiology that forms the basis for the development of various targeted drug delivery approaches in cancer chemotherapy.

中文翻译：

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用于控制抗癌药物释放的γ-聚谷氨酸纳米颗粒的生产和表征。

γ-聚谷氨酸（γ-PGA）是一种亲水的，可生物降解的，天然存在的生物聚合物，它由多种微生物物种（最常见的杆菌科）生产。它的生物学特性（例如无毒，生物相容性和非免疫原性）使其成为药物递送应用中的重要生物材料。这项审查主要侧重于作为抗癌治疗药物传递载体的γ-PGA纳米粒子的发展。我们讨论了γ-PGA纳米粒子的生产和表征以及控释策略的各种技术。我们还介绍了肿瘤生理学的简要概述，该概述为癌症化疗中各种靶向药物递送方法的开发奠定了基础。