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The brucellae and their success as pathogens.
Critical Reviews in Microbiology ( IF 6.5 ) Pub Date : 2007-11-23 , DOI: 10.1080/10408410701647644
Humberto Guerra 1
Affiliation  

Brucellae are tiny, aerobic, slow growing, catalase and oxidase positive Gram negative coccobacilli or small rods, which may reach man through exposure to tissues of mammalian hosts via cuts or aerosols, or as food infections mostly through dairy products. As parasites brucellae are extraordinarily successful, causing very long-lasting infections in all mammalian social animals, such as ungulates, canids, and rodents; recently they have been found to also cause disease in pinnipeds and cetaceans. Brucellae as members of the alpha Proteobacteria, have suffered major losses of genomic material as they adapted to their facultative intracellular parasite role, and are able to initiate infection with minimal disturbance of the innate immune system, thus reaching a privileged intracellular niche where they multiply. Brucellae are likely to be among the toughest organisms to control through public health and agricultural policies, even involving detection-slaughter strategies.

中文翻译:

布鲁氏菌及其作为病原体的成功。

布鲁氏菌是微小的,好氧的,生长缓慢的,过氧化氢酶和氧化酶阳性的革兰氏阴性球菌或小杆,它们可能通过割伤或气雾剂暴露于哺乳动物宿主的组织中,或者主要通过乳制品作为食物感染而到达人体。由于布鲁氏菌是非常成功的寄生虫,因此在所有哺乳动物的社会动物(例如有蹄类动物,犬科动物和啮齿类动物)中都造成了非常长期的感染;最近,它们也被发现也引起了nip鱼和鲸类动物的疾病。布鲁氏菌属作为α变形杆菌的成员,由于适应了兼性的细胞内寄生虫作用而遭受了基因组材料的重大损失,并且能够以对先天免疫系统的最小干扰来开始感染,从而达到了在细胞内繁殖的特权。
更新日期:2019-11-01
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