ABSTRACT The beta-2 adrenergic receptor (ADRB2) regulates the proliferation, apoptosis, angiogenesis, migration, and metastasis of cancer cells. However, its function in the progression of clear cell renal cell carcinoma (ccRCC) is unknown. Here, we report that ADRB2 can be a novel prognostic factor for patients with ccRCC. The differential expression of ADRB2 in low-stage (stages I and II), high-stage (stages III and IV), low-grade (grades I and II), and high-grade (grades III and IV) ccRCC was identified in cohorts of patients from The Cancer Genome Atlas and the International Cancer Genome Consortium. We evaluated ADRB2 expression as a prognostic factor using the Kaplan-Meier survival curve, multivariate analysis, time-dependent area under the curve (AUC) of Uno’s C-index, and AUC of the receiver operating characteristics (ROC) at five years. Kaplan-Meier analysis revealed that reduced ADRB2 expression is associated with poor prognosis in ccRCC patients. Analysis of C-indices and AUC-ROC further confirmed this result. Moreover, multivariate analysis confirmed the prognostic significance of ADRB2 expression. Collectively, these findings suggest that ADRB2 is a potential prognostic factor for ccRCC.

中文翻译：

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β-2 肾上腺素能受体在透明细胞肾细胞癌中的预后作用

摘要 β-2 肾上腺素能受体 (ADRB2) 调节癌细胞的增殖、凋亡、血管生成、迁移和转移。然而，其在透明细胞肾细胞癌 (ccRCC) 进展中的作用尚不清楚。在这里，我们报告 ADRB2 可以成为 ccRCC 患者的新预后因素。ADRB2 在低分期（I 和 II 期）、高分期（III 和 IV 期）、低级（I 和 II 级）和高级（III 和 IV 级）ccRCC 中的差异表达在来自癌症基因组图谱和国际癌症基因组联盟的患者队列。我们使用 Kaplan-Meier 生存曲线、多变量分析、时间依赖的 Uno C 指数曲线下面积 (AUC) 和 5 年接收者操作特征 (ROC) 的 AUC 评估 ADRB2 表达作为预后因素。Kaplan-Meier 分析显示 ADRB2 表达降低与 ccRCC 患者的不良预后相关。C 指数和 AUC-ROC 的分析进一步证实了这一结果。此外，多变量分析证实了 ADRB2 表达的预后意义。总的来说，这些发现表明 ADRB2 是 ccRCC 的潜在预后因素。