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Age of Red Cells for Transfusion and Outcomes in Critically Ill Patients: A Meta-Analysis
Transfusion Medicine and Hemotherapy ( IF 2.2 ) Pub Date : 2019-01-01 , DOI: 10.1159/000498863
Wei Zhang 1 , Kun Yu 1 , Ni Chen 1 , Miao Chen 1
Affiliation  

Objective: Whether the age of red blood cells (RBCs) affects mortality after transfusion in critically ill patients is controversial. Methods: We searched MEDLINE, EMBASE, PubMed, Web of Science, and the Cochrane Library Central Register of Controlled Trials databases from inception to January 10, 2018 to identify systematic reviews or meta-analyses and published randomized controlled trials of the effects of fresh versus older blood transfusion on mortality of adults in the intensive care unit (ICU). There were no date restrictions, but the language was restricted to English. The primary outcome was mortality. Risk ratios (RR) and 95% confidence intervals (CI) were calculated. Results: We included six trials that enrolled 8,467 critically ill patients and compared fresh RBC transfusion with current standard practice. There were no significant differences in 90-day mortality (RR 1.04, 95% CI 0.97, 1.12), 28/30-day mortality (RR 1.04, 95% CI 0.96, 1.13), in-hospital mortality (RR 1.06, 95% CI 0.94, 1.19), and in-ICU mortality (RR 1.11, 95% CI 0.97, 1.27) with fresh RBC transfusion compared with older blood transfusion. Conclusions: The study concluded that age of red cells for transfusion did not affect the outcomes in critically ill patients.

中文翻译:

危重患者输血的红细胞年龄和结果:荟萃分析

目的:红细胞(RBCs)的年龄是否会影响危重患者输血后的死亡率是有争议的。方法:我们检索了 MEDLINE、EMBASE、PubMed、Web of Science 和 Cochrane Library Central Register of Controlled Trials 数据库,从开始到 2018 年 1 月 10 日,以确定系统评价或荟萃分析,并发表了关于新鲜与对照试验效果的随机对照试验。老年输血对重症监护病房(ICU)成人死亡率的影响。没有日期限制,但语言仅限于英语。主要结果是死亡率。计算了风险比 (RR) 和 95% 置信区间 (CI)。结果:我们纳入了 6 项试验,招募了 8,467 名危重患者,并将新鲜红细胞输注与当前的标准做法进行了比较。90天死亡率(RR 1.04, 95% CI 0.97, 1.12)、28/30天死亡率(RR 1.04, 95% CI 0.96, 1.13)、住院死亡率(RR 1.06, 95%)没有显着差异CI 0.94, 1.19) 和 ICU 内死亡率 (RR 1.11, 95% CI 0.97, 1.27) 与较旧的输血相比,新鲜 RBC 输血。结论:该研究得出结论,用于输血的红细胞年龄不影响危重患者的预后。
更新日期:2019-01-01
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