The RecA protein is a recombinase functioning in recombinational DNA repair in bacteria. RecA is regulated at many levels. The expression of the recA gene is regulated within the SOS response. The activity of the RecA protein itself is autoregulated by its own C-terminus. RecA is also regulated by the action of other proteins. To date, these include the RecF, RecO, RecR, DinI, RecX, RdgC, PsiB, and UvrD proteins. The SSB protein also indirectly affects RecA function by competing for ssDNA binding sites. The RecO and RecR, and possibly the RecF proteins, all facilitate RecA loading onto SSB-coated ssDNA. The RecX protein blocks RecA filament extension, and may have other effects on RecA activity. The DinI protein stabilizes RecA filaments. The RdgC protein binds to dsDNA and blocks RecA access to dsDNA. The PsiB protein, encoded by F plasmids, is uncharacterized, but may inhibit RecA in some manner. The UvrD helicase removes RecA filaments from RecA. All of these proteins function in a network that determines where and how RecA functions. Additional regulatory proteins may remain to be discovered. The elaborate regulatory pattern is likely to be reprised for RecA homologues in archaeans and eukaryotes.

中文翻译：

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调节细菌RecA蛋白的功能。

RecA蛋白是在细菌中重组DNA修复中起作用的重组酶。RecA在许多级别受到监管。recA基因的表达在SOS反应中受到调节。RecA蛋白本身的活性由其自身的C端自动调节。RecA还受其他蛋白质作用的调节。迄今为止，这些蛋白包括RecF，RecO，RecR，DinI，RecX，RdgC，PsiB和UvrD蛋白。SSB蛋白还通过竞争ssDNA结合位点间接影响RecA功能。RecO和RecR以及可能的RecF蛋白都有助于RecA加载到SSB涂层的ssDNA上。RecX蛋白会阻止RecA细丝延伸，并可能对RecA活性产生其他影响。DinI蛋白可稳定RecA细丝。RdgC蛋白与dsDNA结合，并阻止RecA访问dsDNA。由F质粒编码的PsiB蛋白，未表征，但可能以某种方式抑制RecA。UvrD解旋酶从RecA中去除RecA细丝。所有这些蛋白质都在决定RecA在何处以及如何发挥作用的网络中发挥作用。其他调节蛋白可能仍有待发现。对于古细菌和真核生物中的RecA同源物，精心设计的监管模式可能会被取代。