Streptococcus pneumoniae is a causative agent for community acquired pneumonia, bacteremia, acute otitis media, and meningitis. Recent emergence of multi-drug resistant clinical isolates prompts the need of effective vaccine for the prevention of disease. The licensed polysaccharide-based pneumococcal vaccines only elicit protective antibodies against the infection of serotypes that are included in the vaccine. To broaden the protection, the use of pneumococcal proteins will be a feasible and preferable alternative. This communication provides a review on the biochemical properties of these protein candidates, their immunization results in animal studies, and perspectives on the development of protein-based pneumococcal vaccine.

中文翻译：

---

肺炎链球菌蛋白疫苗候选者：特性，活性和动物研究。

肺炎链球菌是社区获得性肺炎，菌血症，急性中耳炎和脑膜炎的病原体。最近出现的多药耐药临床分离株提示需要有效的疫苗来预防疾病。许可的基于多糖的肺炎球菌疫苗仅会引发针对疫苗中所含血清型感染的保护性抗体。为了扩大保护范围，使用肺炎球菌蛋白将是一种可行且更可取的选择。该交流提供了有关这些蛋白质候选物的生化特性，其在动物研究中的免疫结果以及基于蛋白质的肺炎球菌疫苗开发前景的综述。