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Chemical genetics to chemical genomics: small molecules offer big insights.
Chemical Society Reviews ( IF 46.2 ) Pub Date : 2005-09-03 , DOI: 10.1039/b312875j
David R Spring 1
Affiliation  

Chemical genetics is the study of biological systems using small molecule ('chemical') intervention, instead of only genetic intervention. Cell-permeable and selective small molecules can be used to perturb protein function rapidly, reversibly and conditionally with temporal and quantitative control in any biological system. This tutorial review has been written to introduce this emerging field to a broad audience and focuses later on areas of biology where either it has made a significant impact, or it has the potential to do so: signalling, cytoskeleton, development, protein-protein interactions and gene transcription.

中文翻译:

从化学遗传学到化学基因组学:小分子提供了广阔的见识。

化学遗传学是对生物系统的研究,它使用小分子(“化学”)干预,而不仅仅是遗传干预。细胞可渗透的选择性小分子可用于在任何生物系统中通过时间和定量控制快速,可逆和有条件地干扰蛋白质功能。编写本教程的评论是为了向广大读者介绍这个新兴领域,并在以后重点介绍生物学已产生重大影响或具有潜力的生物学领域:信号传导,细胞骨架,发育,蛋白质-蛋白质相互作用和基因转录。
更新日期:2019-11-01
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