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Pharmacokinetics of tolfenamic acid in Hawksbill turtles (Eretmochelys imbricata) after single intravenous and intramuscular administration.
Journal of Veterinary Pharmacology and Therapeutics ( IF 1.3 ) Pub Date : 2019-11-09 , DOI: 10.1111/jvp.12823
Natsuda Raweewan 1 , Weerapong Laovechprasit 2 , Mario Giorgi 3 , Thanaphan Chomcheun 2 , Narumol Klangkaew 1 , Kanjana Imsilp 1 , Amnart Poapolathep 1 , Saranya Poapolathep 1
Affiliation  

To the best of our knowledge, limited pharmacokinetic information to establish suitable therapeutic plans is available for Hawksbill turtles. Therefore, the present study aimed to assess the pharmacokinetic features of tolfenamic acid (TA) in Hawksbill turtles, Eretmochelys imbricata, after single intravenous (i.v.) and intramuscular (i.m.) administration at dosage 4 mg/kg body weight (b.w.). The study (parallel design) used 10 Hawksbill turtles randomly divided into equal groups. Blood samples were collected at assigned times up to 144 hr. The concentrations of TA in plasma were quantified by a validated liquid chromatography tandem mass spectrometry (LC-ESI-MS/MS). The concentration of TA in the experimental turtles with respect to time was pharmacokinetically analyzed using a noncompartment model. The Cmax values of TA were 89.33 ± 6.99 µg/ml following i.m. administration. The elimination half-life values were 38.92 ± 6.31 hr and 41.09 ± 9.32 hr after i.v. and i.m. administration, respectively. The absolute i.m. bioavailability was 94.46%, and the average binding percentage of TA to plasma protein was 31.39%. TA demonstrated a long half-life and high bioavailability following i.m. administration. Therefore, the i.m. administration is recommended for use in clinical practice because it is both easier to perform and provides similar plasma concentrations to the i.v. administration. However, further studies are needed to determine the clinical efficacy of TA for treatment of inflammatory disease after single and multiple dosages.

中文翻译:

单次静脉内和肌肉内给药后,en草酸在Hawk中的药代动力学。

据我们所知,Hawk鱼的药代动力学信息有限,无法建立合适的治疗方案。因此,本研究旨在评估在剂量为4 mg / kg体重(bw)的单次静脉内(iv)和肌内(im)给药后,Hawk草酸(TA)在Hawk中的药代动力学特征。该研究(平行设计)使用了10只随机分成相等组的Hawk。在指定的时间(最多144小时)收集血液样本。血浆中TA的浓度通过验证的液相色谱串联质谱(LC-ESI-MS / MS)进行定量。使用非隔离室模型,用药代动力学方法分析了实验龟中TA的浓度。TA的Cmax值为89.33±6。即时给药后为99 µg / ml。静脉和肌内注射后,消除半衰期值分别为38.92±6.31小时和41.09±9.32小时。绝对的绝对生物利用度为94.46%,TA与血浆蛋白的平均结合率为31.39%。即时给药后,TA显示出长的半衰期和高的生物利用度。因此,建议将im给药用于临床实践,因为它不仅易于执行,而且提供与iv给药相似的血浆浓度。然而,需要进一步的研究来确定单剂和多剂后TA治疗炎性疾病的临床疗效。绝对的绝对生物利用度为94.46%,TA与血浆蛋白的平均结合率为31.39%。即时给药后,TA显示出长的半衰期和高的生物利用度。因此,建议将im给药用于临床实践,因为它不仅易于执行,而且提供与iv给药相似的血浆浓度。但是,需要进一步的研究以确定单剂和多剂后TA治疗炎性疾病的临床疗效。绝对的绝对生物利用度为94.46%,TA与血浆蛋白的平均结合率为31.39%。即时给药后,TA显示出长的半衰期和高的生物利用度。因此,建议将im给药用于临床实践,因为它不仅易于执行,而且提供与iv给药相似的血浆浓度。然而,需要进一步的研究来确定单剂和多剂后TA治疗炎性疾病的临床疗效。建议在临床实践中使用静脉注射,因为它不仅易于执行,而且提供与静脉注射相似的血浆浓度。但是,需要进一步的研究以确定单剂和多剂后TA治疗炎性疾病的临床疗效。建议在临床实践中使用静脉注射,因为它不仅易于执行,而且提供与静脉注射相似的血浆浓度。但是,需要进一步的研究以确定单剂和多剂后TA治疗炎性疾病的临床疗效。
更新日期:2019-11-01
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