The number of ribosomes in a cell is considered as limiting, and gene expression is thus largely determined by their cellular concentration. In this work we develop a toy model to study the trade-off between the ribosomal supply and the demand of the translation machinery, dictated by the composition of the transcript pool. Our equilibrium framework is useful to highlight qualitative behaviours and new means of gene expression regulation determined by the fine balance of this trade-off. We also speculate on the possible impact of these mechanisms on cellular physiology.

中文翻译：

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核糖体竞争的平衡模型。

细胞中核糖体的数目被认为是限制性的，因此基因表达在很大程度上取决于它们的细胞浓度。在这项工作中，我们开发了一个玩具模型来研究核糖体供应与翻译机需求之间的权衡，该权衡取决于笔录库的组成。我们的平衡框架对于强调定性行为和基因表达调控的新手段非常有用，这种新的手段由这种权衡取舍决定。我们还推测这些机制可能对细胞生理学的影响。