The goal of present work is the study of NO releasing mechanisms in nitrofuroxanoquinoline (NFQ) derivatives. Mechanisms of their structural non-rigidity and pathways of NO donation - spontaneous or under the action of sulfanyl radicals or photoirradiation - were considered in details, both experimentally and quantum chemically. Furoxan-containing systems of the discussed type are not capable of spontaneous or photoinduced decomposition under mild conditions, and sulfanyl (radical) induced processes are the most preferable. It was shown that appropriate modification of NFQ through [3 + 2] cycloaddition and subsequent aromatization is a powerful tool to design new prospective donors of NO molecule. Two newly obtained NFQ derivatives were proven to have unusually high NO activity in full accordance with the theoretical model. We hope that these examples will encourage community to seek for new NO active molecules among cycloadducts and modified furoxanes.

中文翻译：

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硝基呋喃基喹啉的综合研究。NO分子的新观点供体。

目前工作的目的是研究硝基呋喃基喹啉（NFQ）衍生物中NO的释放机理。在实验和量子化学方面都详细考虑了其结构非刚性的机理以及自发或在亚硫烷基自由基或光辐射作用下的NO捐赠途径。所讨论类型的含呋喃喃的体系在温和条件下不能自发或光诱导分解，最优选硫烷基（自由基）诱导的过程。结果表明，通过[3 + 2]环加成和随后的芳构化对NFQ进行适当修饰是设计新的NO分子预期供体的有力工具。完全按照理论模型证明，两种新获得的NFQ衍生物具有异常高的NO活性。