Only a profound understanding of the structure and function of cells - either as single units or in the context of tissues and whole organisms - will allow a comprehension of what happens in pathological conditions and provides the means to fight disease. The Cell Biology and Infection (BCI for Biologie Cellulaire et Infection) department was created in 2002 at the Institut Pasteur in Paris to develop a research program under the umbrella of cell biology, infection biology and microbiology. Its visionary ambition was to shape a common framework for cellular microbiology, and to interface the latter with hard sciences like physics and mathematics and cutting-edge technology. This concept, ahead of time, has given high visibility to the field of cellular microbiology and quantitative cell biology, and it has allowed the successful execution of highly interdisciplinary research programs linking a molecular understanding of cellular events with disease. Now, the BCI department embraces additional pathologies, namely cancer and neurodegenerative diseases. Here, we will portray how the integrative research approach of BCI has led to major scientific breakthroughs during the last ten years, and where we see scientific opportunities for the near future.

中文翻译：

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两全其美-在巴斯德研究所将细胞生物学与感染融合在一起。

只有深刻了解细胞的结构和功能（无论是作为单个单元还是在组织和整个生物体的情况下），才能理解病理情况下发生的事情，并提供与疾病作斗争的手段。细胞生物学与感染（BCI for Biologie Cellulaire等机构）系于2002年在巴黎巴斯德研究所成立，目的是在细胞生物学，感染生物学和微生物学的保护下制定一项研究计划。它的远见卓识在于塑造细胞微生物学的通用框架，并使后者与诸如物理学，数学和尖端技术之类的硬科学相互联系。提前提出这一概念，已使细胞微生物学和定量细胞生物学领域具有很高的知名度，并且它已经成功执行了高度跨学科的研究计划，该计划将对细胞事件与疾病的分子理解联系在一起。现在，BCI部门采用了其他病理，即癌症和神经退行性疾病。在这里，我们将描述BCI的综合研究方法如何在过去十年中带来了重大的科学突破，以及在不久的将来我们将看到哪些科学机遇。