In 1989 ILAR published a list and description of immunodeficient rodents used in research. Since then, advances in understanding of molecular mechanisms; recognition of genetic, epigenetic microbial, and other influences on immunity; and capabilities in manipulating genomes and microbiomes have increased options and opportunities for selecting mice and designing studies to answer important mechanistic and therapeutic questions. Despite numerous scientific breakthroughs that have benefitted from research in mice, there is debate about the relevance and predictive or translational value of research in mice. Reproducibility of results obtained from mice and other research models also is a well-publicized concern. This review summarizes resources to inform the selection and use of immune relevant mouse strains and stocks, aiming to improve the utility, validity, and reproducibility of research in mice. Immune sufficient genetic variations, immune relevant spontaneous mutations, immunodeficient and autoimmune phenotypes, and selected induced conditions are emphasized.

中文翻译：

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免疫相关和免疫缺陷小鼠：转化研究的选择和机会。

1989年，ILAR公布了用于研究的免疫缺陷型啮齿动物的清单和描述。从那时起，对分子机制的了解不断提高；认识遗传，表观微生物以及其他对免疫力的影响；操纵基因组和微生物组的能力和能力为选择小鼠和设计研究以回答重要的机制和治疗问题提供了更多选择和机会。尽管得益于小鼠研究，科学方面取得了许多突破，但有关小鼠研究的相关性和预测性或转化性的价值仍存在争议。从小鼠和其他研究模型获得的结果的可重复性也是众所周知的问题。这篇评论总结了一些资源，以指导选择和使用与免疫相关的小鼠品系和种群，以提高其实用性，小鼠研究的有效性和可重复性。强调了足够的遗传变异，免疫相关的自发突变，免疫缺陷和自身免疫表型以及选择的诱导条件。