Over the past decade, newly introduced methods for apheresis platelet collection have led to increased collection yields. This has resulted in "splitting," which allows transfusion of 2 patients from 1 high-yield collection. Although many small studies exist, no large studies have described the impact of methodological changes on routine blood center collections. We constructed a database containing selected parameters from 45,224 apheresis collections spanning July 1997 to April 2002, using Gambro BCT Spectra (Lakewood, CO), Fenwal CS-3000+ (Baxter Healthcare Corp, Fenwal Division, Deerfield, IL), and Baxter Amicus instruments. A Baker 9110+ hematology analyzer (Bio Chem Immunosystems, Inc., Allentown, PA) was used for platelet counting. Monthly average collection yields, distribution yields (product platelet contents after splitting), and split rates (the fraction of donations which may be split) were determined. The monthly mean collection yield and split rate correlated very closely. Both rose throughout the study period. The split rate climbed from 25% to 70% by study end. However, mean monthly distribution yields decreased by 7% because split and unsplit platelet yields both rose as split rates rose. Overcollections with the Amicus correlated with underestimation of donors' true preprocedure platelet counts during machine programming. Undercollections occurred in donors with low counts and, with-single needle Amicus, microcytic platelet collection. These results may assist in the optimization of an apheresis program. Increased collection yields correlated with cell separator type, dual-needle access, donor platelet count >250 x 10(9)/L, programming with true preprocedure platelet counts and capacity for triple product preparation from collection yields exceeding 2-bag storage capacity.

中文翻译：

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改善通过单采血液收集血小板的技术：在一个血液中心拥有5年经验。

在过去的十年中，新引入的单采血液采血小板收集方法提高了收集产量。这导致“分裂”，从而允许从1个高产量收集物中输注2位患者。尽管存在许多小型研究，但尚无大型研究描述方法改变对常规血液中心采集的影响。我们使用Gambro BCT Spectra（科罗拉多州拉克伍德），Fenwal CS-3000 +（Baxter Healthcare Corp，Fenwal Division，Deerfield，IL）和Baxter Amicus仪器构建了一个数据库，其中包含1997年7月至2002年4月从45,224个血液分离术收集中选择的参数。使用Baker 9110+血液分析仪（Bio Chem Immunosystems，Inc.，Allentown，PA）进行血小板计数。月平均收集量，分配量（分裂后的产品血小板含量），确定分摊率（可以分摊的捐款比例）。月平均收集量与拆分率密切相关。在整个研究期间，两者均上升。到研究结束时，拆分率从25％攀升至70％。但是，平均月度分配收益下降了7％，因为拆分和未拆分的血小板产量都随着拆分率的增加而增加。机器编程过程中，由于输液器收集过多而导致捐赠者的术前血小板计数被低估。捐献者数量少，单针A孔小细胞血小板收集不足。这些结果可能有助于单采程序的优化。与细胞分离器类型，双针进入，供体血小板计数> 250 x 10（9）/ L相关的增加的收集产量，