The purpose of this study was to ascertain the optimal pharmacokinetic model for milrinone in pediatric patients after cardiac surgery when milrinone was administered as a slow loading dose followed by a constant-rate infusion. The data used for pharmacokinetic analysis were collected in a prospective, randomized, placebo-controlled multi-center trial of milrinone as prophylaxis for the development of low cardiac output syndrome after surgery for repair of complex congenital cardiac defects. Two blood samples were randomly collected from each patient for determination of plasma milrinone concentrations with subsequent population pharmacokinetic modeling. The pharmacokinetics of milrinone in pediatric patients under 6 year's age were best described by a weight-normalized one compartment model after a slow loading dose followed by a constant-rate infusion. The volume of distribution was 482 ml kg(-1) and was independent of age. Clearance was a linear function of age given by Cl = 2.42 ml kg(-1) min(-1) [1 + 0.396*age].

中文翻译：

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小儿心脏手术后米力农的总体药代动力学分析。

这项研究的目的是确定米力农在慢速负荷剂量后以恒定剂量输注米力农后，在心脏外科手术后小儿患者中米力农的最佳药代动力学模型。在一项前瞻性，随机，安慰剂对照的多中心米力农试验中收集了用于药代动力学分析的数据，以预防术后复杂先天性心脏缺陷的低心排血综合征的发展。从每位患者中随机采集两个血样，以测定血浆中米力农的浓度，并进行随后的群体药代动力学建模。米力农在6岁以下儿童中的药代动力学 缓慢加载剂量后再进行恒定速率输注后，通过体重标准化的一个隔室模型可以最好地描述其年龄。分布的体积为482 ml kg（-1），与年龄无关。清除率是Cl = 2.42 ml kg（-1）min（-1）[1 + 0.396 * age]给出的年龄的线性函数。