This article includes a retrospective review of fatalities caused by transfusion-related acute lung injury (TRALI) over a 5-year period (from 1997 to 2002) that were reported to the Center for Biologics Evaluation and Research involving 58 recipient deaths and the corresponding 63 blood component donors. Descriptive statistics are presented. Recipient characteristics include age, sex, and admitting diagnosis. Cardiovascular disease, pulmonary disorders, and cancer were the most frequent diagnoses of transfusion recipients. Reported deaths did not appear to be associated with age, sex, reason for transfusion, or transfusion component. Implicated blood component(s) and clinical symptoms at the time of reaction were recorded. Fresh frozen plasma was implicated in one half of the cases, whereas red blood cells played a role in approximately one third. The clinical characteristics described most often in TRALI reports included shortness of breath, frothy sputum, pulmonary infiltrates, and hypoxia. Donor variables included age, sex, parity, and laboratory tests for antibodies to HLA and/or antigranulocyte antibodies. Laboratory tests showed HLA antibodies and/or antigranulocyte antibodies were positive in the majority of donors tested. More data are needed to better describe the role of antibodies in these reactions. Greater awareness is crucial for the practitioner to be alert for signs and symptoms of TRALI and to be aware of the necessary steps in treatment.

中文翻译：

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由TRALI造成的死亡。

本文包括一项回顾性研究，回顾了过去5年（1997年至2002年）因输血相关的急性肺损伤（TRALI）所致的死亡人数，该死亡事故已报告给生物制品评估与研究中心，涉及58位接受者死亡和63位死亡血液成分供体。介绍了描述性统计数据。收件人特征包括年龄，性别和入学诊断。心血管疾病，肺部疾病和癌症是输血接受者的最常见诊断。报告的死亡似乎与年龄，性别，输血原因或输血成分无关。记录反应时涉及的血液成分和临床症状。在一半的病例中涉及新鲜的冷冻血浆，而在大约三分之一的病例中红细胞起作用。TRALI报告中最经常描述的临床特征包括呼吸急促，痰浊，肺浸润和缺氧。供体变量包括针对HLA和/或抗粒细胞抗体的年龄，性别，均等性和实验室测试。实验室测试显示，在大多数测试的供体中，HLA抗体和/或抗粒细胞抗体是阳性的。需要更多数据以更好地描述抗体在这些反应中的作用。增强意识对于从业者警惕TRALI的体征和症状以及了解治疗的必要步骤至关重要。以及针对HLA和/或抗粒细胞抗体的实验室测试。实验室测试显示，在大多数测试的供体中，HLA抗体和/或抗粒细胞抗体是阳性的。需要更多数据以更好地描述抗体在这些反应中的作用。增强意识对于从业者警惕TRALI的体征和症状以及了解治疗的必要步骤至关重要。以及针对HLA和/或抗粒细胞抗体的实验室测试。实验室测试显示，在大多数测试的供体中，HLA抗体和/或抗粒细胞抗体是阳性的。需要更多数据以更好地描述抗体在这些反应中的作用。增强意识对于从业者警惕TRALI的体征和症状以及了解治疗的必要步骤至关重要。