Nitric oxide (NO) is a gaseous molecule with an astonishingly wide range of physiological and pathophysiological activities, including the regulation of vessel tone and angiogenesis in wound healing, inflammation, ischaemic cardiovascular diseases and malignant diseases. Recent data have revealed the predominant role of endothelial nitric oxide synthase (eNOS), an endothelial-cell-specific isoform of NO producing enzyme, in both angiogenesis (the development of new blood vessels derived from existing vessels) and vasculogenesis (blood vessel formation de novo from progenitor cells). In addition, successes in gene therapy, together with the recent development of an eNOS-specific inhibitor, suggest that the modulation of eNOS might be a potent new strategy for the control of pathological neovascularization.

中文翻译：

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eNOS在新生血管形成中的作用：内皮祖细胞的NO。

一氧化氮（NO）是一种气体分子，具有惊人的广泛的生理和病理生理活动，包括在伤口愈合，炎症，缺血性心血管疾病和恶性疾病中调节血管张力和血管生成。最近的数据表明，内皮一氧化氮合酶（eNOS）（一种产生NO的内皮细胞特异性同工型）在血管生成（从现有血管衍生的新血管的发育）和血管生成（血液形成始祖细胞）。此外，基因治疗的成功以及eNOS特异性抑制剂的最新开发表明，eNOS的调节可能是控制病理性新血管形成的有效新策略。