Systemic sclerosis (SSc) may overlap frequently with other rheumatic diseases, including systemic lupus erythematosus (SLE), which can require high-dose steroids depending on the clinical presentation. We present a case involving this overlap in which the patient concomitantly developed lupus nephritis and Coombs (+) hemolytic anemia, which was confused with scleroderma renal crisis. In this condition, assessing for lupus nephritis with timely renal biopsy and lupus serology can aid in guiding the appropriate treatment. We discuss the clinical features and challenging management of this case with a review of the English-language literature for SSc and SLE overlap with glomerulonephritis.

中文翻译：

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肾小球肾炎和库姆斯阳性溶血性贫血，类似于硬皮病，在系统性红斑狼疮和弥漫性系统性硬化的重叠中发生肾病。

系统性硬化症（SSc）可能与其他风湿性疾病频繁重叠，包括系统性红斑狼疮（SLE），根据临床表现可能需要大剂量的类固醇。我们介绍了一个涉及此重叠的病例，其中患者同时发展为狼疮性肾炎和库姆斯（+）溶血性贫血，后者与硬皮病肾病相混淆。在这种情况下，及时进行肾活检和狼疮血清学检查以评估狼疮性肾炎可以帮助指导适当的治疗。我们通过回顾SSc和SLE与肾小球肾炎重叠的英语文献来讨论该病例的临床特征和具有挑战性的治疗方法。